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Landiolol

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Identification
Molecular formula
C22H29NO3Si
CAS number
114413-55-3
IUPAC name
2-(dimethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate
State
State

Landiolol is primarily found as a solid at room temperature. It is stable in this form and is usually provided as a powder for pharmaceutical use. It is important to handle it under appropriate environmental conditions to maintain its integrity and efficacy.

Melting point (Celsius)
150.00
Melting point (Kelvin)
423.15
Boiling point (Celsius)
413.90
Boiling point (Kelvin)
687.05
General information
Molecular weight
463.71g/mol
Molar mass
463.7090g/mol
Density
1.0450g/cm3
Appearence

Landiolol typically appears as a white to off-white crystalline powder. Its exact appearance may vary depending on the form and any impurities present, but it generally retains this characteristic look, ensuring identification in pure samples.

Comment on solubility

Solubility of 2-(dimethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate

The solubility of 2-(dimethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate in various solvents showcases some interesting characteristics. Understanding its solubility is crucial for applications in pharmaceuticals and chemical processes.

Key Points about Solubility:

  • Polar solvents: This compound is expected to have a moderate solubility in polar solvents due to the presence of the dimethylamino group, which can engage in hydrogen bonding.
  • Non-polar solvents: Due to the bulky trimethylsilyl moiety, the compound may also demonstrate some solubility in non-polar solvents, though it might be less than in polar solvents.
  • Influence of pH: The solubility can also be influenced by the pH of the solution, particularly because of the amine functional group that can be protonated under acidic conditions, potentially enhancing solubility.
  • Temperature effect: Like many compounds, increasing temperature may lead to increased solubility, particularly in solid forms.

In summary, the solubility of 2-(dimethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate is multifaceted and can vary based on the choice of solvent, temperature, and pH. Careful consideration of these factors is essential when working with this compound in practical applications.

Interesting facts

Interesting Facts about 2-(Dimethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate

This compound is a fascinating example of organic chemistry, showcasing the interplay between structural complexity and biological activity. Here are some intriguing aspects to consider:

  • Functional Groups: The presence of both dimethylamino and hydroxy functional groups contributes to the compound's interesting reactivity and interactions with biomolecules. This is significant in the fields of medicinal chemistry and drug design.
  • Silylation: The use of a trimethylsilyl group is not just a structural choice; it can enhance lipophilicity, helping the compound to penetrate various biological membranes. This plays a crucial role in the development of pharmaceuticals.
  • Analytical Importance: Compounds like this are valuable in analytical chemistry. Due to their structural complexity, they often serve as standards in chromatography, particularly in liquid chromatography and mass spectrometry.
  • Potential Applications: Researchers are investigating the applications of such compounds in various domains, including neuroscience, where their potential effects on neurotransmitter systems are being explored.
  • Structural Diversity: This compound exemplifies structural diversity, with multiple functional groups and steric variations. Understanding such diversity is key to synthesizing new derivatives with enhanced properties.

In summary, 2-(dimethylamino)ethyl 3-hydroxy-3-methyl-2-(4-trimethylsilylphenyl)butanoate is not just an ordinary compound but a focal point of research and application in organic and medicinal chemistry. Its multifaceted nature exemplifies how structure correlates with function in chemical compounds.