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Cinnarizine

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Identification
Molecular formula
C26H28ClN3O3
CAS number
298-57-7
IUPAC name
but-2-enedioic acid;2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate
State
State

Cinnarizine is typically encountered as a solid at room temperature.

Melting point (Celsius)
119.00
Melting point (Kelvin)
392.15
Boiling point (Celsius)
446.80
Boiling point (Kelvin)
719.80
General information
Molecular weight
368.87g/mol
Molar mass
368.8810g/mol
Density
1.2406g/cm3
Appearence

Cinnarizine appears as a fine, white to almost white powder. It is only slightly soluble in water but more soluble in dimethylformamide and slightly soluble in ethanol.

Comment on solubility

Solubility of but-2-enedioic acid; 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate

The solubility of a compound can greatly influence its applications and behavior in various environments. For the compound but-2-enedioic acid; 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate, understanding its solubility is particularly significant due to its complex structure which combines elements that may exhibit differing solubility characteristics.

  • Polar vs. Nonpolar Regions: The presence of both polar functional groups (like the carboxylic acid of but-2-enedioic acid) and nonpolar aromatic systems (from the benzoate part of the compound) can lead to intriguing solubility behavior. Such structures often show enhanced solubility in water or organic solvents depending on the arrangement and interactions of these groups.
  • Effect of Chain Length: The piperazine and aliphatic chains may influence solubility, with longer hydrocarbon chains typically reducing solubility in polar solvents while increasing it in nonpolar solvents.
  • Temperature Sensitivity: Like many organic compounds, the solubility can be temperature-dependent, meaning that increased temperatures can increase solubility in some solvents, showcasing the dynamic nature of this interaction.

Thus, it is essential to note that the unique hybrid nature of this compound’s structure means that solubility testing in various solvents can yield critical data needed for practical applications. As formulated, this compound may require specific conditions to achieve optimal solubility, making empirical testing a valuable approach in understanding its full potential in practical scenarios.

Interesting facts

Interesting Facts about But-2-enedioic Acid

But-2-enedioic acid, commonly known as fumaric acid, is a fascinating compound with a variety of significant applications. Here are some intriguing aspects:

  • Biological Importance: Fumaric acid plays a crucial role in the Krebs cycle, which is essential for cellular respiration in many organisms. It is involved in energy production and metabolism.
  • Therapeutic Use: This compound is used in the treatment of certain skin conditions, particularly psoriasis. It has anti-inflammatory properties and has shown effectiveness in reducing skin plaques.
  • Flavoring Agent: Interestingly, fumaric acid is also utilized as a food additive. It imparts a pleasant acidity to various food products, enhancing their flavor profiles.
  • Industrial Applications: It serves as an important intermediate in the synthesis of various esters and is used in the manufacture of resins, plastics, and certain dyes.

As a chemical student or scientist, understanding the multifaceted uses of but-2-enedioic acid can open doors to numerous fields, ranging from biochemistry to materials science. Its versatility underscores the importance of organic compounds in both nature and industry.

Exploring the Structural Complexity

The structure of but-2-enedioic acid allows for various reactions due to its unsaturated bonds. This reactivity is pivotal in both synthetic organic chemistry and biological processes. In the lab, it can serve as a building block, enhancing the synthesis of more complex compounds.

In conclusion, but-2-enedioic acid is more than just a simple dicarboxylic acid; it is a compound vital to life and industry, showcasing the intricate relationships between organic chemistry and biological functionality.


Exploring 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate

This compound, known for its complex structure, is a remarkable example in medicinal chemistry. Here are some compelling points about it:

  • Pharmaceutical Applications: The compound is associated with treatments for various psychiatric disorders, primarily due to its tricyclic structure, which allows it to interact effectively with neurotransmitter receptors in the brain.
  • Synthesis and Chemistry: The intricate synthesis of this compound involves multiple steps, showcasing the art of organic synthesis. Each functional group plays a specific role in its overall activity.
  • Structure-Activity Relationship (SAR): Understanding the relationship between its structural components and biological activity is crucial in drug development. Insights gained can lead to optimized therapeutic agents with improved efficacy.
  • Novel Study Paths: Researchers are continually exploring variations of this compound, creating derivatives with heightened activity and lower side effects, paving the way for advances in psychopharmacology.

For chemistry students, this compound serves as an excellent case study in the intersection of organic synthesis, pharmacology, and medicinal chemistry. Each part of its name reflects intricate functionality that can lead to diverse biological effects, which is a testament to the power of chemical modification.

In summary, 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethyl 3,4,5-trimethoxybenzoate is not just a compound of interest for its complexity but also for its potential impact on therapeutic treatments, exemplifying the importance of innovative research in the field of chemistry.