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Combretastatin A-4

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Identification
Molecular formula
C18H19NO3
CAS number
117048-59-6
IUPAC name
but-2-enedioic acid;3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine
State
State

At room temperature, Combretastatin A-4 is in a crystalline solid state.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
465.15
Boiling point (Kelvin)
738.30
General information
Molecular weight
316.36g/mol
Molar mass
316.8280g/mol
Density
1.2000g/cm3
Appearence

Combretastatin A-4 is typically a white to off-white crystalline powder. It can appear as needle-like crystals when purified.

Comment on solubility

Solubility of but-2-enedioic acid;3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine

The compound but-2-enedioic acid;3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine exhibits unique solubility characteristics influenced by its dual functional groups and molecular structure.

Solubility Characteristics:

  • Water Solubility: Due to the presence of acidic and amine functional groups, the compound likely demonstrates varying degrees of solubility in water, particularly at different pH levels.
  • Organic Solvents: The hydrophobic aromatic chlorophenyl group may increase solubility in organic solvents such as ethanol or dimethyl sulfoxide (DMSO), making it more soluble in non-polar environments.
  • Temperature Dependence: Solubility may be affected by temperature, often increasing with higher temperatures, allowing for better dissolution in both aqueous and organic solvents.

In summary, the solubility of but-2-enedioic acid;3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine is complex and can be tailored by altering conditions such as solute concentration, solvent type, and temperature. Understanding these solubility properties is crucial for applications in various chemical and pharmaceutical contexts.

Interesting facts

Interesting Facts about But-2-enedioic Acid

But-2-enedioic acid, commonly known as fumaric acid, is a fascinating organic compound with notable significance in both nature and industry. Here are some intriguing aspects:

  • Natural Source: Fumaric acid is naturally found in certain plants, such as lichen and mushrooms, and plays a crucial role in the citric acid cycle.
  • Applications: It is widely used in the food industry as a food additive (E297), and its sour flavoring attributes make it a popular ingredient in beverages and other consumables.
  • Pharmaceutical Importance: Fumaric acid and its derivatives have been studied for their potential therapeutic properties, particularly in the treatment of multiple sclerosis and psoriasis.
  • Polymer Production: The compound is also a key ingredient in the production of certain synthetic resins, enhancing the properties of plastics and coatings.

Insights on 3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine

This compound is a member of the class of molecules known as amine derivatives and presents unique properties that make it a subject of interest in medicinal chemistry. Here are some notable points:

  • Complex Structure: The intricate architecture of this amine derivative includes a chlorophenyl group and a pyridyl component, which can contribute to its biological activity.
  • Biological Relevance: Compounds with similar structures have been researched for their potential effects on neurotransmitter systems, possibly indicating uses in treating psychiatric or neurological disorders.
  • Research Potential: With ongoing studies in the field of drug discovery, this compound may reveal new therapeutic avenues based on its interactions with biological systems.
  • Versatile Applications: Amine compounds are widely used in the development of various pharmaceuticals, agrochemicals, and as intermediates in organic synthesis, showcasing their versatility.
Synonyms
113-92-8
Chloropheniramine maleate
HMS3369F09
HMS3371M22
HMS3373A05
HMS3393L14
HMS3394E15
HMS3655G14
BCP09631
AKOS030228309
SB19136
PD046142
SY058031
DB-041191
NS00079398
(Z)-but-2-enedioic acid,(3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine