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Clozapine

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Identification
Molecular formula
C18H19ClN4
CAS number
5786-21-0
IUPAC name
but-2-enedioic acid;5-methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine
State
State

At room temperature, Clozapine is a solid. Its crystalline nature contributes to its stability in solid form.

Melting point (Celsius)
183.50
Melting point (Kelvin)
456.70
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
326.83g/mol
Molar mass
326.8320g/mol
Density
1.2800g/cm3
Appearence

Clozapine appears as a white to yellowish crystalline powder. It has poor water solubility, but is soluble in methanol, acetone, and chloroform.

Comment on solubility

Solubility Insights

But-2-enedioic acid (cis-2-butenoic acid or fumaric acid) is a compound known for its dietary significance and solubility characteristics. Its solubility can be influenced by various factors including:

  • pH of the solution: The acid is more soluble in alkaline conditions due to deprotonation.
  • Temperature: Increased temperatures generally enhance the solubility of organic acids.
  • Solvent polarity: But-2-enedioic acid exhibits higher solubility in polar solvents like water compared to nonpolar solvents.

In contrast, 5-methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine presents a more complex solubility profile. This structure suggests:

  • Hydrophobic interactions: Due to its extensive aromatic system, the compound is likely to be less soluble in water but may dissolve in organic solvents.
  • Functional group influence: The presence of a piperidine ring can enhance solubility in specific organic mediums.
  • Polarity factors: The overall solubility is significantly affected by the balance between hydrophilic and hydrophobic groups in its molecular structure.

In summary, while but-2-enedioic acid is relatively soluble in aqueous environments, 5-methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine demonstrates a more nuanced solubility dominated by its structural characteristics. Understanding these solubility behaviors is crucial for their application in various fields such as pharmaceuticals and biochemistry.

Interesting facts

Interesting Facts about But-2-enedioic Acid

But-2-enedioic acid, commonly known as fumaric acid, is a fascinating organic compound that plays a significant role in various biochemical processes. Here are some key points to consider:

  • Biological Importance: Fumaric acid is an intermediate in the Krebs cycle, a crucial metabolic pathway that generates energy in aerobic organisms. It is essential for converting carbohydrates, fats, and proteins into energy.
  • Health Applications: This compound has been studied for its therapeutic potential in treating conditions such as psoriasis and multiple sclerosis. In fact, fumaric acid esters have been used in clinical settings to manage these conditions.
  • Industrial Use: Fumaric acid is utilized in the production of resins, food additives, and as a flavoring agent in the food industry. Its acidic properties make it a valuable component in various chemical syntheses.
  • Natural Occurrence: It can be found in certain fungi and can be derived from the fermentation of sugar by yeast, demonstrating its natural origin and relevance in biochemical processes.

The diverse applications and biological significance of but-2-enedioic acid make it an intriguing compound in both organic chemistry and pharmacology.

Interesting Facts about 5-Methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine

This compound, known as a bioactive molecule, has piqued the interest of scientists for its unique structure and potential applications. Here are some captivating aspects:

  • Complex Structure: The intricate structure of 5-methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine allows for specific interactions in biological systems, highlighting the importance of molecular geometry in drug design.
  • Potential as a Neuroleptic: Compounds of this class are often explored for their neuroleptic properties, offering potential benefits in treating psychiatric disorders by influencing neurotransmitter activity in the brain.
  • Research Focus: Ongoing studies aim to understand the pharmacodynamics and pharmacokinetics of this compound, providing insights into how it behaves in biological systems and its possible therapeutic implications.
  • Versatile Applications: Beyond its potential in psychiatry, such compounds are being researched for their anti-inflammatory and analgesic properties, indicating their broad scope in medicinal chemistry.

The exploration of 5-methyl-11-[3-(1-piperidyl)propyl]-6,11-dihydrobenzo[c][1]benzazepine exemplifies the exciting intersection of chemical structure and biological activity, underscoring the continual quest for novel therapeutics in the field of medicinal chemistry.