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Clonazepam

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Identification
Molecular formula
C15H10ClN2O3
CAS number
1622-61-3
IUPAC name
but-2-enedioic acid;7-chloro-1-[3-[4-(2-ethoxyethyl)piperazin-1-yl]propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
State
State

Clonazepam is a solid at room temperature. It is stable under normal conditions and does not readily degrade when exposed to air, moisture, or light.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.00
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.00
General information
Molecular weight
315.71g/mol
Molar mass
315.7140g/mol
Density
1.3000g/cm3
Appearence

Clonazepam appears as a light yellow crystalline powder. It is generally odorless and has a slightly bitter taste. Due to its crystalline nature, clonazepam reflects light, which can cause it to sparkle under certain conditions.

Comment on solubility

Solubility of but-2-enedioic acid;7-chloro-1-[3-[4-(2-ethoxyethyl)piperazin-1-yl]propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one

When considering the solubility of this complex compound, several factors come into play due to its intricate structure:

  • Polarity: The presence of polar functional groups contributes to the solubility in polar solvents like water. However, the presence of non-polar aromatic rings can hinder this solubility.
  • Hydrogen Bonding: The capability of but-2-enedioic acid to form hydrogen bonds enhances solubility in aqueous solutions, while the piperazine moiety could also aid in solubilizing the entire structure.
  • Solvent Compatibility: This compound may exhibit variable solubility depending on the solvent used, being more soluble in organic solvents such as ethanol or DMSO, rather than in non-polar solvents.
  • Concentration Effects: The solubility is often concentration-dependent; at higher concentrations, the solubility may differ due to interactions between solute molecules.

In summary, while *but-2-enedioic acid* facilitates solubility due to its acidic nature and potential for hydrogen bonding, the presence of large hydrophobic regions in the benzodiazepine structure may create challenges. Consequently, it's essential to consider the specific solvent and concentration when evaluating its overall solubility profile.

Interesting facts

Interesting Facts about But-2-enedioic Acid and Its Derivatives

But-2-enedioic acid, commonly known as fumaric acid, is an intriguing compound with various applications and implications in both chemistry and medicine. Here are some notable facts to consider:

  • Natural Occurrence: Fumaric acid is naturally found in certain lichen species and in the metabolism of various organisms, including humans. It plays a role in the citric acid cycle, an essential process for energy production.
  • Health Benefits: This compound has been associated with potential therapeutic benefits, especially in the treatment of psoriasis and multiple sclerosis. It is believed that it helps modulate the immune response.
  • Chemical Reactions: But-2-enedioic acid can undergo various reactions, including esterification and decarboxylation, making it a versatile intermediate in organic synthesis.

Exploring a Complex Derivative

The compound 7-chloro-1-[3-[4-(2-ethoxyethyl)piperazin-1-yl]propyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one represents a sophisticated derivative with potential pharmaceutical applications. Consider the following aspects:

  • Drug Development: This compound can be a candidate in the synthesis of new drugs, particularly in the development of anxiolytic and sedative agents due to its benzodiazepine structure.
  • Structure-Activity Relationship: Understanding how modifications to its structure, such as the addition of the 2-ethoxyethyl group, affect its biological activity is crucial for optimizing pharmacological properties.
  • Fluorine Substitution: The presence of fluorine in the 2-position of the phenyl ring can significantly enhance the stability and lipophilicity of the compound, affecting its interaction with biological targets.

In conclusion, both but-2-enedioic acid and its complex derivatives offer a rich field of study, showcasing their significance in natural processes and potential therapeutic applications. As scientists continue to study these compounds, our understanding of their mechanisms and benefits can greatly expand.