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Diazepam

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Identification
Molecular formula
C16H13ClFN2O
CAS number
439-14-5
IUPAC name
but-2-enedioic acid;7-chloro-5-(2-fluorophenyl)-1-[3-(4-methylpiperazin-1-yl)propyl]-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, diazepam is typically found in a solid state, commonly manufactured in tablet form for medical use. It is stable under atmospheric pressure and normal temperatures but susceptible to light and moisture.

Melting point (Celsius)
131.00
Melting point (Kelvin)
404.00
Boiling point (Celsius)
309.00
Boiling point (Kelvin)
582.00
General information
Molecular weight
284.74g/mol
Molar mass
284.7370g/mol
Density
1.3000g/cm3
Appearence

Diazepam occurs as a colorless to light yellow crystalline compound. It may also appear as a white or off-white powder. When exposed to high temperatures, the compound can emit toxic fumes, including hydrogen chloride, nitrogen oxides, and carbon monoxide.

Comment on solubility

Solubility of but-2-enedioic acid; 7-chloro-5-(2-fluorophenyl)-1-[3-(4-methylpiperazin-1-yl)propyl]-3H-1,4-benzodiazepin-2-one

The solubility of this compound is influenced by multiple factors, particularly its structural characteristics. Here are some key points to consider:

  • Polarity: The presence of both polar and non-polar groups in the molecule means that solubility may vary in different solvents.
  • Aromatic rings: The inclusion of aromatic systems often leads to better solubility in organic solvents, which may not be the case in polar solvents.
  • Functional groups: But-2-enedioic acid, as a dicarboxylic acid, is expected to have reasonable solubility in water due to its carboxyl (-COOH) groups.
  • Interactions: The ability of the compound to form hydrogen bonds might enhance its solubility in certain solvents, while steric hindrance due to bulky groups could impede solubility in others.

To summarize, while the but-2-enedioic acid component may demonstrate good solubility in water, the overall solubility of this complex compound is likely to be dependent on the balance of polar and nonpolar interactions, making predictive solubility assessments require careful consideration of specific solvent environments.

Interesting facts

Exploring But-2-enedioic Acid

But-2-enedioic acid, more commonly known as fumaric acid, is an intriguing compound with a number of notable features in both chemistry and biochemistry.

  • Biological Relevance: Fumaric acid plays a crucial role in the Krebs cycle, an essential metabolic pathway that generates energy in living organisms. It is a key intermediate in cellular respiration, highlighting its importance in energy production.
  • Health Benefits: Fumaric acid derivatives have been studied for their potential use in treating multiple sclerosis and psoriasis, owing to their immunosuppressive properties.
  • Food Industry: As a food additive, it is often used as a flavoring agent or acidity regulator in various products, further emphasizing its role in everyday life.

Fumaric acid is synthesized from malic acid and exhibits a range of chemical properties that make it an excellent candidate for various chemical reactions, including its use in the synthesis of polyesters. Its characteristic double bond contributes to its reactivity, making it an interesting subject of study for chemists.

Fumaric Acid in Synthesis

This compound is especially valued in organic synthesis. Notable uses include:

  • Synthesis of Esters: Fumaric acid can react with alcohols to form esters, which are essential in the production of perfumes and flavors.
  • Cross-Coupling Reactions: Its double bond enables it to participate in cross-coupling reactions, facilitating complex molecule construction.

In conclusion, but-2-enedioic acid is more than just a simple dicarboxylic acid; it serves significant roles in biological systems and industrial applications. Its versatility and relevance underscore its importance in chemistry and beyond.

Dive into 7-Chloro-5-(2-fluorophenyl)-1-[3-(4-methylpiperazin-1-yl)propyl]-3H-1,4-benzodiazepin-2-one

The compound 7-chloro-5-(2-fluorophenyl)-1-[3-(4-methylpiperazin-1-yl)propyl]-3H-1,4-benzodiazepin-2-one is a complex and fascinating member of the benzodiazepine family, known for its diverse pharmacological properties.

  • Mechanism of Action: Like many benzodiazepines, this compound is believed to enhance the effect of the neurotransmitter GABA (gamma-aminobutyric acid) at the GABAA receptor. This action leads to anxiolytic, sedative, and muscle relaxant effects.
  • Therapeutic Applications: Due to its specific structure, it has potential applications in treating a variety of conditions including anxiety disorders and epilepsy.
  • Research Insights: The unique combination of substituents highlights the ongoing research in the field of medicinal chemistry, as scientists explore modifications that could enhance therapeutic effectiveness or reduce side effects.

This compound's detailed structure reflects the intricate nature of its design, showcasing how small changes in chemical structure can dramatically influence biological activity and pharmacodynamics. Understanding its properties not only elucidates its potential applications but also offers insights into the broader field of drug development.

In summary, exploring compounds like 7-chloro-5-(2-fluorophenyl)-1-[3-(4-methylpiperazin-1-yl)propyl]-3H-1,4-benzodiazepin-2-one reveals the intricate relationship between chemical structure and function, paving the way for advancements in therapeutic strategies.