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Clorazepate

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Identification
Molecular formula
C16H11ClN2O3
CAS number
57109-90-7
IUPAC name
but-2-enedioic acid;7-chloro-5-phenyl-1-[2-(1-piperidyl)ethyl]-3H-1,4-benzodiazepin-2-one
State
State

Clorazepate is a solid at room temperature.

Melting point (Celsius)
243.50
Melting point (Kelvin)
516.70
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.00
General information
Molecular weight
408.86g/mol
Molar mass
408.8610g/mol
Density
1.3691g/cm3
Appearence

Clorazepate is typically encountered as a white or almost white fine crystalline powder. It is often odorless and may appear in tablet forms for pharmaceutical use.

Comment on solubility

Solubility of But-2-enedioic Acid and 7-Chloro-5-phenyl-1-[2-(1-piperidyl)ethyl]-3H-1,4-benzodiazepin-2-one

Understanding the solubility of chemical compounds is crucial for their application in various fields such as pharmaceuticals, agriculture, and materials science. Here we examine the solubility characteristics of two specific compounds: but-2-enedioic acid and 7-chloro-5-phenyl-1-[2-(1-piperidyl)ethyl]-3H-1,4-benzodiazepin-2-one.

But-2-enedioic Acid (C4H4O4)

But-2-enedioic acid, also known as maleic acid, is known for its soluble nature, particularly in:

  • Water: Highly soluble, allowing for easy incorporation into aqueous reactions.
  • Alcohols: Soluble in both ethanol and methanol, making it useful in organic synthesis.
  • Acetone: Exhibits good solubility, enhancing its versatility in organic solvents.

This solubility is attributed to its ability to form hydrogen bonds due to the presence of carboxylic acid groups, which makes it quite reactive and functional in various chemical processes.

7-Chloro-5-phenyl-1-[2-(1-piperidyl)ethyl]-3H-1,4-benzodiazepin-2-one

The solubility of 7-chloro-5-phenyl-1-[2-(1-piperidyl)ethyl]-3H-1,4-benzodiazepin-2-one is generally more complex and can be influenced by a variety of factors:

  • Solvents: It may show moderate solubility in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol but is less soluble in more polar solvents.
  • pH Dependence: The solubility may vary significantly with changes in pH, due to the presence of nitrogen atoms that can engage in protonation.
  • Drug Formulation: In pharmaceutical applications, enhancing solubility may require special formulations like salt forms or co-solvents.

As a result, researchers often need to evaluate solubility carefully for effective use in clinical settings and drug development.

In summary, understanding the solubility profiles of these compounds not only informs their practicality in applications but also guides scientists in expanding their usage in innovative ways.

Interesting facts

Interesting Facts about But-2-enedioic Acid

But-2-enedioic acid, commonly known as fumaric acid, is a fascinating compound with a variety of applications in both biochemistry and industry. Here are some intriguing insights:

  • Biochemical Significance: Fumaric acid plays a crucial role in the Krebs cycle, a fundamental metabolic pathway that helps convert food into energy.
  • Therapeutic Uses: This compound is known for its efficacy in treating psoriasis and has been studied for its potential in managing multiple sclerosis due to its anti-inflammatory properties.
  • Food Additive: Fumaric acid is also used as a food additive, imparting a sour flavor and acting as a preservative. It’s often found in beverages and various food products.
  • Polymer Applications: In the world of materials science, it is used in the production of unsaturated polyesters, which are integral in the manufacturing of fiberglass and resins.

Overall, but-2-enedioic acid is not only pivotal in biological systems but also versatile in various industrial contexts.


Overview of 7-Chloro-5-phenyl-1-[2-(1-piperidyl)ethyl]-3H-1,4-benzodiazepin-2-one

This compound belongs to the class of benzodiazepines, a group of psychoactive drugs known for their calming effects. Here’s what makes this compound particularly interesting:

  • Psychoactive Effects: Benzodiazepines are widely recognized for their anxiolytic, sedative, and anticonvulsant properties, which make them valuable in treating anxiety, insomnia, and seizure disorders.
  • Research in Pharmacology: The unique chemical structure of this compound allows for various interactions within the central nervous system, making it a subject of intensive pharmacological research.
  • Derivative Development: Compounds like this one inspire the development of new medications with improved efficacy and reduced side effects, showcasing the ever-evolving landscape of medicinal chemistry.
  • Synergistic Studies: Researchers actively investigate the effects of this compound in combination with other medications, exploring potential enhancements in therapeutic outcomes.

This specific benzodiazepine derivative provides invaluable insights into medicinal chemistry and drug development, reflecting the complexities and innovations inherent in pharmacological research.