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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
34552-83-5
IUPAC name
2-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenyl-acetamide
State
State
Loperamide is in the solid state at room temperature.
Melting point (Celsius)
214.50
Melting point (Kelvin)
487.65
Boiling point (Celsius)
617.80
Boiling point (Kelvin)
890.95
General information
Molecular weight
477.03g/mol
Molar mass
477.0340g/mol
Density
1.1973g/cm3
Appearence
Loperamide is a white or almost white powder. It appears as a crystalline solid and is practically insoluble in water, slightly soluble in methanol, and freely soluble in chloroform.
Comment on solubility

Solubility of 2-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenyl-acetamide

The solubility of 2-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenyl-acetamide is an interesting topic, primarily due to its complex structure. Several factors influence its solubility, which can be understood as follows:

  • Polarity: Being a large organic molecule, its solubility in water is likely to be low. The presence of non-polar phenyl groups tends to decrease water solubility.
  • Solvent Interactions: The compound may exhibit better solubility in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and acetone, which can disrupt the intermolecular forces present in the compound.
  • Temperature Effects: Generally, increasing the temperature can enhance solubility in organic solvents, making it essential to consider temperature when evaluating solubility characteristics.

For practical applications, the solubility behavior of this compound can vary, and it is essential to conduct empirical studies to establish precise solubility limits under different conditions. As always, understanding the solubility is crucial for formulating effective formulations and achieving desired concentrations in potential therapeutic applications.

Interesting facts

2-Ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenyl-acetamide

This intriguing compound belongs to the class of amides and showcases a complex structure characterized by both ethoxy and diphenyl groups. It serves as a fascinating example of how various functional groups can be combined to create molecules with unique properties.

Highlights of 2-Ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenyl-acetamide

  • Diverse Functional Groups: This compound features a blend of ethoxy, methyl, and diphenyl functionalities, offering a rich platform for studying interactions between different chemical moieties.
  • Potential Bioactivity: Compounds with similar structures have been explored for their biological activity, making them of interest in medicinal chemistry. They could potentially exhibit properties that are useful in therapeutic applications.
  • Synthetically Interesting: The construction of this compound involves multi-step synthetic pathways, showcasing the creativity and ingenuity of chemists as they manipulate chemical reactions to achieve complex structures.
  • Applications: While the specific applications of this compound may not be widely documented, compounds within this category are often examined for roles as pharmaceuticals, agrochemicals, or laboratory reagents.

The intricacies of 2-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenyl-acetamide exemplify the depth of research and exploration in the field of organic chemistry. Understanding such compounds not only enriches our chemical knowledge but also contributes to the advancement of various applications in science and industry.

Synonyms
Carbifene
carbiphene
Carbifeno
Carbifene [INN:BAN]
UNII-NJQ5FL8Q43
NJQ5FL8Q43
CARBIFENE [INN]
CARBIPHENE [MI]
CARBIPHENE [WHO-DD]
DTXSID20166152
2-ETHOXY-N-METHYL-N-(2-(METHYLPHENETHYLAMINO)ETHYL)-2,2-DIPHENYLACETAMIDE
BENZENEACETAMIDE, .ALPHA.-ETHOXY-N-METHYL-N-(2-(METHYL(2-PHENYLETHYL)AMINO)ETHYL)-.ALPHA.-PHENYL-
DTXCID3088643
BENZENEACETAMIDE, ALPHA-ETHOXY-N-METHYL-N-(2-(METHYL(2-PHENYLETHYL)AMINO)ETHYL)-ALPHA-PHENYL-
Etomide
15687-16-8
Carbiphene; Etomide; Etymide
2-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenylacetamide
Etymide hydrochloride
Carbifenum
alpha-Ethoxy-N-methyl-N-[2-[methyl(phenethyl)amino]ethyl]-alpha-phenylbenzeneacetamide
NSC106959
2-Ethoxy-N-methyl-N-(2-(methyl(2-phenylethyl)amino)ethyl)-2,2-diphenylacetamide
SCHEMBL24346
CHEMBL2110882
CHEBI:135698
GLXC-06483
Carbiphene (USAN)(*hydrochloride*)
2-Ethoxy-N-methyl-N-(2-(methylphenethylamino)ethyl)-2,2-diphenylacetamid
Acetamide, 2-ethoxy-N-methyl-N-[2-(methylphenethylamino)ethyl]-2,2-diphenyl-
2-Ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-di(phenyl)acetamide
NCGC00408834-01
NS00003290
Q27284901
2-ethoxy-N-methyl-N-[2-[methyl(phenethyl)amino]ethyl]-2,2-diphenyl-acetamide
{2-Ethoxy-N-methyl-N-[[2-(methylphenethyl)amino]ethyl]-2,} 2-diphenylacetamide hydrochloride
{2-Ethoxy-N-methyl-N-[2-(methylphenethylamino)ethyl]-2,} 2-diphenylacetamide monohydrochloride
Acetamide, {2-ethoxy-N-methyl-N-[[2-(methylphenethyl)amino]ethyl]-2,} 2-diphenyl-, hydrochloride
Acetamide, {2-ethoxy-N-methyl-N-[2-(methylphenethylamino)ethyl]-2,2-diphenyl-,} monohydrochloride
Benzeneacetamide, {.alpha.-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-.a} lpha.-phenyl-, monohydrochloride