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Diphenoxylate hydrochloride

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Identification
Molecular formula
C30H32ClNO2
CAS number
37780-68-6
IUPAC name
2-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenyl-acetamide;hydrochloride
State
State

At room temperature, diphenoxylate hydrochloride is generally in a solid state.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
273.00
Boiling point (Kelvin)
546.15
General information
Molecular weight
489.06g/mol
Molar mass
489.0550g/mol
Density
1.2650g/cm3
Appearence

Diphenoxylate hydrochloride usually appears as a white crystalline powder. It is typically odourless and tasteless.

Comment on solubility

Solubility of 2-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenyl-acetamide; hydrochloride

The solubility of this compound can be influenced by a variety of factors, including its chemical structure and the nature of the solvent used. Here are some key points to consider about its solubility:

  • This compound is typically expected to be soluble in polar solvents due to the presence of the hydrochloride form.
  • Hydrochlorides tend to exhibit good solubility in water because of their ionic nature.
  • The presence of the ethoxy and diphenyl groups might affect the overall polarity and thus the solubility profile.
  • In organic solvents such as ethanol and methanol, the solubility may also be favorable due to the ability of these solvents to interact with the aromatic structures present.

As a general observation:

  • Higher temperatures often increase solubility for many compounds.
  • When exploring solubility, it can be beneficial to conduct empirical tests, as theoretical predictions may not always capture intricacies.

In conclusion, while the solubility of 2-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenyl-acetamide in various solvents presents promising prospects, empirical evaluation is crucial for definitive insights.

Interesting facts

Interesting Facts about 2-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenyl-acetamide; hydrochloride

This compound, often referred to in the context of its pharmacological applications, is a member of the acetamide class and showcases a fascinating profile due to its intricate structure and potential biological activities.

Key Points of Interest:

  • Pharmacological Significance: The compound is evaluated for its therapeutic potential, particularly in the realm of central nervous system (CNS) disorders. Its various substitutions may influence interactions with neurotransmitter systems.
  • Molecular Complexity: The presence of multiple phenyl groups and an ethoxy chain grants the molecule a complex architecture, which can contribute to unique pharmacokinetic properties.
  • Research Undertakings: Ongoing studies are exploring the implications of its use in pain management and neuropharmacology, making it an interesting candidate for future drug development.
  • Structure-Activity Relationship (SAR): Understanding how the modifications in the molecular structure affect its biological activity can offer crucial insights, guiding chemists in designing more effective derivatives.

As we investigate 2-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenyl-acetamide; hydrochloride, we are reminded of the intricate dance between chemistry and biology. This compound encapsulates the essence of medicinal chemistry, where small changes in a molecule can lead to significant changes in its efficacy and safety profile. The study of such compounds not only enhances our understanding of medicinal applications but also paves the way for new therapeutic avenues.

Synonyms
Carbiphene hydrochloride
Carbiphene HCl
Bandol
467-22-1
Jubalon
Carbifene hydrochloride
Etomide hydrochloride
NSC-106959
Carbiphene hydrochloride [USAN]
Etymide hydrochloride
SQ 10269
SQ 10,269
7L93SJ2K9A
SQ-10269
2-Ethoxy-N-methyl-N-(2-(methylphenethylamino)ethyl)-2,2-diphenylacetamide monohydrochloride
Carbiphene hydrochloride (USAN)
2-ethoxy-N-methyl-N-(2-(methyl(phenethyl)amino)ethyl)-2,2-diphenylacetamide hydrochloride
2-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-2,2-diphenylacetamide;hydrochloride
Benzeneacetamide, alpha-ethoxy-N-methyl-N-[2-[methyl(2-phenylethyl)amino]ethyl]-alpha-phenyl-, hydrochloride (1:1)
NSC106959
EINECS 207-389-8
NSC 106959
UNII-7L93SJ2K9A
2-Ethoxy-N-methyl-N-[2-(methylphenethylamino)ethyl]-2,2-diphenylacetamide monohydrochloride
Bandol (TN)
2-Ethoxy-N-methyl-N-(2-(methylphenethylamino)ethyl)-2,2-diphenylacetamide hydrochloride
Benzeneacetamide, alpha-ethoxy-N-methyl-N-(2-(methyl(2-phenylethyl)amino)ethyl)-alpha-phenyl-, monohydrochloride
SCHEMBL121168
CHEMBL2106487
DTXSID00196912
DQPNQXUUCWOWCK-UHFFFAOYSA-N
CARBIPHENE HYDROCHLORIDE [MI]
AKOS040745649
Acetamide, 2-ethoxy-N-methyl-N-(2-(methylphenethylamino)ethyl)-2,2-diphenyl-, hydrochloride
Acetamide,2-diphenyl-, monohydrochloride
CARBIPHENE HYDROCHLORIDE [WHO-DD]
Acetamide, 2-ethoxy-N-methyl-N-(2-(methylphenethylamino)ethyl)-2,2-diphenyl-, monohydrochloride
WLN: 2OXR&R&VN1&2M2R D1 &GH
NS00080558
D03389
Q27268515
2-Ethoxy-N-methyl-N-[[2-(methylphenethyl)amino]ethyl]-2,2-diphenylacetamide hydrochloride
BENZENEACETAMIDE, .ALPHA.-ETHOXY-N-METHYL-N-(2-(METHYL(2-PHENYLETHYL)AMINO)ETHYL)-.ALPHA.-PHENYL-, MONOHYDROCHLORIDE