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Amifostine

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Identification
Molecular formula
C7H16NO2PS
CAS number
20537-88-6
IUPAC name
2-[ethoxy(methyl)phosphoryl]sulfanyl-N,N-diethyl-ethanamine
State
State

At room temperature, amifostine is typically in a solid state, appearing as a crystalline powder. It is stable under standard conditions of temperature and pressure.

Melting point (Celsius)
97.00
Melting point (Kelvin)
370.20
Boiling point (Celsius)
305.20
Boiling point (Kelvin)
578.40
General information
Molecular weight
214.25g/mol
Molar mass
214.2530g/mol
Density
1.2048g/cm3
Appearence

Amifostine is a white crystalline powder. It can also appear as fine, yellowish-white crystals. Its physical form and color can vary slightly based on the purity and form of the compound available.

Comment on solubility

Solubility of 2-[ethoxy(methyl)phosphoryl]sulfanyl-N,N-diethyl-ethanamine

The solubility of 2-[ethoxy(methyl)phosphoryl]sulfanyl-N,N-diethyl-ethanamine can be influenced by various factors, making it an interesting compound for study.

Factors Affecting Solubility:

  • Polarity: The presence of both ethoxy and phosphoryl groups contributes to the overall polarity of the compound. Generally, more polar compounds have higher solubility in polar solvents.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds with solvents can enhance solubility. The amine group may participate in hydrogen bonding, affecting its solubility in water.
  • Chain Length: The ethyl groups on the amine can introduce hydrophobic characteristics, which may decrease solubility in polar solvents but increase it in nonpolar environments.

In aqueous solutions, the solubility might be moderate due to the balance between polar and nonpolar characteristics. It is important to consider that:

  1. The **ethoxy group** may increase solubility in alcohols and other organic solvents.
  2. **Temperature** can play a significant role; generally, solubility increases with temperature for solids in liquids.
  3. **pH Levels:** The charge state of the amine group can also change depending on the solution's pH, further impacting solubility.

In conclusion, while 2-[ethoxy(methyl)phosphoryl]sulfanyl-N,N-diethyl-ethanamine exhibits intriguing solubility properties, comprehensive empirical studies are necessary to accurately determine its solubility limits across various solvents.

Interesting facts

Interesting Facts about 2-[Ethoxy(methyl)phosphoryl]sulfanyl-N,N-diethyl-ethanamine

This compound, with its complex structure, showcases the fascinating interplay between organic and inorganic chemistry. It belongs to a class of compounds known as phosphoramidothioates, which are often studied for their unique properties and potential applications.

Key Features

  • Phosphoryl Group: The presence of a phosphoryl group indicates potential reactivity, especially in biological systems. Phosphorylation plays a crucial role in cellular processes and signaling.
  • Sulfanyl Functionality: The sulfanyl group suggests that this compound may exhibit interesting chemical behaviors, including nucleophilicity and catalytic properties.
  • Ether Linkage: The ethoxy group contributes to the overall stability of the molecule, while also influencing its solubility and reactivity.
  • Amine Component: The N,N-diethyl-ethanamine moiety introduces basicity to the compound, allowing for potential interactions in various chemical contexts.

Applications: Compounds like this are not only of academic interest but also have potential industrial applications. They can be explored in fields such as:

  • Pharmaceuticals: Investigating bioactivity and therapeutic effects.
  • Agriculture: Developing pesticides or herbicides.
  • Catalysis: Serving as catalysts in various organic reactions.

As scientists continue to explore the properties of 2-[ethoxy(methyl)phosphoryl]sulfanyl-N,N-diethyl-ethanamine, the potential for developing new applications is promising. The integration of phosphorous and sulfur in its structure allows for intricate reactions that chemists eagerly study.

In summary, this compound is more than just a collection of atoms; it embodies a myriad of possibilities waiting to be uncovered in the diverse world of chemistry.

Synonyms
Edemo
21770-86-5
Edemo 3
2XM5EU7NUM
2-[ethoxy(methyl)phosphoryl]sulfanyl-N,N-diethylethanamine
S-2-Diethylaminoethyl-O-ethylester kyseliny methylthiofosfonove
Phosphonothioic acid, methyl-, S-(2-(diethylamino)ethyl) O-ethyl ester
O-ETHYL-S-[2-(DIETHYLAMINO)ETHYL]METHYLPHOSPHONOTHIATE
2-(ethoxy(methyl)phosphoryl)sulfanyl-N,N-diethylethanamine
S-(2-(Diethylamino)ethyl) O-ethyl P-methylphosphonothioate
S-[2-(Diethylamino)ethyl] O-ethyl P-methylphosphonothioate
VM_(nerve agent)
BRN 2251003
UNII-2XM5EU7NUM
RefChem:1098217
SCHEMBL955878
S-[2-(Diethylamino)ethyl] o-ethyl methylphosphonothioate
DTXSID40865014
S-2-Diethylaminoethyl-O-ethylester kyseliny methylthiofosfonove [Czech]
NS00120427
Q2068532
S-2-Diethylaminoethyl O-ethyl methylphosphonothioate
O-Ethyl S-(2-diethylaminoethyl) methylthiophosphonate
O-Ethyl S-2-diethylaminoethyl methylphosphonothiolate
o-Ethyl S-2-(diethylamino)ethyl methylphosphonothiolate
ethyl {[2-(diethylamino)ethyl]sulfanyl}(methyl)phosphinate
O-ethyl S-2-(N,N-diethylamino)ethyl methylthio-phosphonate
Methyl-phosphonothioic acid S-(2-diethylamino-ethyl) ester O-ethyl ester
Phosphonothioic acid, P-methyl-, S-[2-(diethylamino)ethyl] O-ethyl ester