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2-Ethylbenzimidazole

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Identification
Molecular formula
C9H10N2
CAS number
938-65-2
IUPAC name
2-ethyl-1H-benzimidazole
State
State

At room temperature, 2-Ethylbenzimidazole is in the solid state, typically found as a white to off-white crystalline powder.

Melting point (Celsius)
111.00
Melting point (Kelvin)
384.15
Boiling point (Celsius)
364.00
Boiling point (Kelvin)
637.15
General information
Molecular weight
146.20g/mol
Molar mass
146.1880g/mol
Density
1.1647g/cm3
Appearence

2-Ethylbenzimidazole appears as a white to off-white crystalline powder. The compound is usually in a solid state at room temperature and has a slight aromatic odor characteristic of benzimidazole derivatives.

Comment on solubility

Solubility of 2-ethyl-1H-benzimidazole

2-ethyl-1H-benzimidazole, a derivative of benzimidazole, exhibits interesting solubility characteristics that can vary depending on the solvent used. Here are some key points regarding its solubility:

  • Polar Solvents: It tends to have low solubility in polar solvents like water due to the presence of the ethyl and benzimidazole structure that aren't extensively hydrophilic.
  • Non-polar Solvents: Conversely, 2-ethyl-1H-benzimidazole is more soluble in non-polar organic solvents such as chloroform or ethanol, making it more compatible in organic synthesis and applications.
  • Temperature Influence: The solubility of this compound can increase with temperature, which is often the case for organic compounds.
  • pH Sensitivity: Changes in pH can also affect the solubility, especially in polar environments where benzimidazole can participate in protonation reactions.

Overall, understanding the solubility profile of 2-ethyl-1H-benzimidazole is crucial for its practical applications in pharmaceuticals and chemical synthesis. As an insightful quote states, "Solubility is often the key to the ultimate utility of a compound in medicinal chemistry."

Interesting facts

Interesting Facts about 2-Ethyl-1H-benzimidazole

2-Ethyl-1H-benzimidazole is a fascinating compound that belongs to the class of benzimidazoles, which are known for their diverse chemical properties and biological activities. Here are some key points that highlight the significance of this compound:

  • Structural Foundation: The benzimidazole structure, containing a fused benzene and imidazole ring, is a core component of many biologically active compounds. This unique arrangement allows for extensive interactions with biological targets.
  • Pharmaceutical Relevance: Compounds from the benzimidazole family have been extensively studied for their pharmaceutical properties, particularly as anthelmintics and anti-tumor agents. Their effectiveness has made them integral in the development of various medications.
  • Versatile Applications: Beyond pharmaceuticals, 2-ethyl-1H-benzimidazole may also find applications in the fields of agriculture as fungicides, as well as in the manufacturing of polymers and coatings.
  • Research Insights: The study of benzimidazoles often reveals their interactions at the molecular level, offering insights into enzyme inhibition and cell signaling pathways, making them an exciting area of research for chemists and biologists alike.
  • Synthesis Pathways: The synthesis of 2-ethyl-1H-benzimidazole can involve various methods, including the reaction of an appropriate ethyl-substituted compound with ortho-phenylenediamine, showcasing the versatility of synthetic chemistry.

In addition to their academic and practical importance, benzimidazole derivatives like 2-ethyl-1H-benzimidazole represent the interplay between structure and function in medicinal chemistry. The ongoing exploration of these compounds can lead to new discoveries that may enhance our understanding of drug action and improve therapeutic efficacy.

Synonyms
2-Ethylbenzimidazole
1848-84-6
2-Ethyl-1H-benzimidazole
1H-Benzimidazole, 2-ethyl-
BENZIMIDAZOLE, 2-ETHYL-
EINECS 217-433-8
NSC 28961
NSC 38878
BRN 0116484
AI3-51842
DTXSID60171664
5-23-06-00436 (Beilstein Handbook Reference)
DTXCID5094155
217-433-8
2-ethyl-1H-benzo[d]imidazole
2-Ethyl-1H-benzoimidazole
MFCD00022684
CHEMBL351569
WLN: T56 BM DNJ C2
2-ethyl-1H-1,3-benzodiazole
2-ethyl benzimidazole
2-Ethyl-Benzimidazole
Enamine_005373
2-Ethyl-1H-benzimidazole #
MLS000532151
SCHEMBL157456
2-ethyl-1H-1,3-benzimidazole
HMS1409E05
HMS2484F04
ALBB-003847
BCP27456
NSC28961
NSC38878
BDBM50404858
NSC-28961
NSC-38878
STK501711
AKOS000275562
NCGC00245718-01
AS-12145
SMR000137092
SY015992
DB-006109
CS-0030568
E1358
NS00026063
EN300-16422
2-Ethyl-1H-benzimidazole;1H-Benzimidazole, 2-ethyl-
Z55692907
F0853-0447
InChI=1/C9H10N2/c1-2-9-10-7-5-3-4-6-8(7)11-9/h3-6H,2H2,1H3,(H,10,11
T91