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Nisoxetine

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Identification
Molecular formula
C17H26N2O
CAS number
60696-78-6
IUPAC name
2-ethyl-2-phenyl-4-(1-piperidyl)butanamide
State
State

At room temperature, Nisoxetine is in a solid state. This compound is typically handled and stored under standard laboratory conditions as a solid substance.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.15
Boiling point (Celsius)
313.00
Boiling point (Kelvin)
586.15
General information
Molecular weight
276.41g/mol
Molar mass
276.4050g/mol
Density
1.1200g/cm3
Appearence

Nisoxetine appears as a fine crystalline powder. The exact color may vary but it typically appears as a white to off-white solid under standard conditions.

Comment on solubility

Solubility of 2-ethyl-2-phenyl-4-(1-piperidyl)butanamide

The solubility of 2-ethyl-2-phenyl-4-(1-piperidyl)butanamide can be influenced by a variety of factors due to its complex structure. Understanding these aspects can help in predicting its behavior in different environments:

  • Polarity: The presence of both hydrophobic (alkyl and aryl groups) and hydrophilic (amine group) portions suggests that this compound may exhibit moderate solubility in organic solvents.
  • Solvent Compatibility: It is likely to be soluble in non-polar organic solvents such as ethanol or dichloromethane, but may have limited solubility in water due to the larger hydrophobic regions.
  • Temperature Effects: Solubility can increase with temperature; hence, higher temperatures might enhance its dissolution in polar solvents.
  • pH Influence: Since the amine group can be protonated, changing the pH could affect solubility, especially in aqueous environments.

In summary, while the exact solubility may vary based on conditions, we can generally anticipate that 2-ethyl-2-phenyl-4-(1-piperidyl)butanamide will show good solubility in organic solvents but limited solubility in water. Thus, understanding the environmental conditions is essential for effective application.

Interesting facts

Interesting Facts about 2-Ethyl-2-phenyl-4-(1-piperidyl)butanamide

2-Ethyl-2-phenyl-4-(1-piperidyl)butanamide is a fascinating compound with a unique structure that contributes to its diverse applications in the field of chemistry and pharmaceuticals. Here are some remarkable aspects of this compound:

  • Structural Diversity: The presence of both an ethyl and a phenyl group in its structure introduces significant steric hindrance, which can influence its reactivity and interactions with biological targets.
  • Pharmacological Potential: Compounds containing a piperidine ring, like this one, are often investigated for their potential pharmacological activities. They may exhibit properties that can be beneficial in treating various disorders, particularly in neuropharmacology.
  • Dual Action: The combination of amide and piperidine functionalities can provide not just receptor binding capabilities but also the potential for enhanced lipophilicity, which can improve the bioavailability of the compound.
  • Synthetic Complexity: The synthesis of this compound involves careful control of reaction conditions to ensure the desired configuration and yield. This complexity can often lead to exciting discoveries in synthetic organic chemistry.
  • Research Interest: Due to its unique molecular properties, 2-ethyl-2-phenyl-4-(1-piperidyl)butanamide is of interest in ongoing research, particularly in the field of drug design where understanding structure-activity relationships is key.

As a chemistry student, examining compounds like this challenges your analytical skills and deepens your understanding of how molecular structure can dictate function. As you study its various facets, consider the potential implications for future research and practical applications in medicine and industry.

“The beauty of chemistry lies in its ability to transform simple structures into complex functionalities.”

Synonyms
2977-21-1
BRN 1348512
BUTYRAMIDE, 2-ETHYL-2-PHENYL-4-PIPERIDINO-
alpha-Ethyl-alpha-(2-piperidinoethyl)phenylacetamide
DTXSID80952199
2-Ethyl-2-phenyl-4-(piperidin-1-yl)butanimidic acid