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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
34552-83-5
IUPAC name
2-ethyl-2-phenyl-4-(1-piperidyl)butanenitrile
State
State

At room temperature, Loperamide is in a solid state. It is typically in the form of a white to slightly off-white crystalline powder.

Melting point (Celsius)
214.50
Melting point (Kelvin)
487.65
Boiling point (Celsius)
555.20
Boiling point (Kelvin)
828.35
General information
Molecular weight
477.06g/mol
Molar mass
477.0580g/mol
Density
0.9285g/cm3
Appearence

Loperamide appears as a white or almost white crystalline powder. It is visually characterized by its fine, silky texture.

Comment on solubility

Solubility of 2-ethyl-2-phenyl-4-(1-piperidyl)butanenitrile

The solubility of 2-ethyl-2-phenyl-4-(1-piperidyl)butanenitrile can be characterized as follows:

General Observations

  • Solvent Polarity: This compound is likely to exhibit limited solubility in polar solvents due to its hydrophobic aromatic and aliphatic groups, while showing improved solubility in non-polar or weakly polar organic solvents.
  • Functional Groups: The presence of the nitrile group (-CN) can facilitate solubility in some polar organic solvents, allowing for potential dissolution in dichloromethane or ethanol.
  • Temperature Dependence: Solubility may also vary with temperature; typically, an increase in temperature enhances the solubility of organic compounds.

Testing for Solubility

To ascertain the precise solubility of 2-ethyl-2-phenyl-4-(1-piperidyl)butanenitrile, the following tests should be conducted:

  1. Check solubility in various organic solvents, starting from non-polar (hexane) to polar (methanol).
  2. Measure the solubility at different temperatures to identify potential temperature effects.
  3. Investigate the influence of pH on solubility, especially if the compound is subjected to aqueous conditions.

In summary, while the solubility profile of 2-ethyl-2-phenyl-4-(1-piperidyl)butanenitrile may suggest moderate solubility in non-polar solvents, further experimental data would be essential to establish its solubility limits accurately.

Interesting facts

Exploring 2-ethyl-2-phenyl-4-(1-piperidyl)butanenitrile

2-ethyl-2-phenyl-4-(1-piperidyl)butanenitrile, often referred to as an intriguing organic compound, finds its place in various fields of chemistry, particularly in medicinal chemistry and drug development. Here are some noteworthy points about this compound:

  • Complex Structure: The molecular architecture of this compound features a butanenitrile backbone which incorporates both ethyl and phenyl groups, creating a basis for unique interactions in biological systems.
  • Biological Relevance: Research has indicated that compounds with piperidine rings often exhibit significant pharmacological properties, making this particular compound a subject of interest for further investigation in drug design.
  • Chirality: The presence of multiple chiral centers within its structure opens avenues for exploring stereochemistry and its impact on the biological activity of related compounds.
  • Potential Applications: With continuous research, there’s potential that derivatives of this compound could be utilized in treating neurological disorders due to the presence of the piperidine moiety.

As scientists and chemistry students delve deeper into the properties and applications of 2-ethyl-2-phenyl-4-(1-piperidyl)butanenitrile, they uncover the layers of complexity behind its chemical behavior and potential contributions to medicinal science. The excitement lies not only in understanding its molecular characteristics but also in exploring how small changes in its structure could lead to impactful discoveries.

"Chemistry is not just about molecules; it's about potential." - A quote to inspire further exploration in the field.

Synonyms
2809-49-6
BRN 0023171
2-Phenyl-2-(2-piperidinoethyl)butyronitrile
BUTYRONITRILE, 2-PHENYL-2-(2-PIPERIDINOETHYL)-
4-20-00-01089 (Beilstein Handbook Reference)
SCHEMBL11649850
DTXSID30950822
2-ETHYL-2-PHENYL-4-(PIPERIDIN-1-YL)BUTANENITRILE