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Celecoxib

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Identification
Molecular formula
C17H14FNO2S
CAS number
169590-42-5
IUPAC name
2-ethylsulfonyl-2-(4-fluorophenyl)-2-phenyl-acetamide
State
State

At room temperature, Celecoxib is in a solid state.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
608.30
Boiling point (Kelvin)
881.50
General information
Molecular weight
381.37g/mol
Molar mass
381.3740g/mol
Density
1.4750g/cm3
Appearence

Celecoxib appears as a white to off-white crystalline powder. It is practically insoluble in water but demonstrates higher solubility in methanol and ethanol.

Comment on solubility

Solubility of 2-ethylsulfonyl-2-(4-fluorophenyl)-2-phenyl-acetamide

2-ethylsulfonyl-2-(4-fluorophenyl)-2-phenyl-acetamide displays intriguing solubility characteristics that can significantly influence its practical applications and behavior in various conditions. Solubility for this compound is primarily dictated by the following factors:

  • Functional Groups: The presence of sulfonamide and aromatic groups greatly affects its solubility in different solvents.
  • Polarity: Given that the compound has both hydrophobic (aromatic) and hydrophilic (sulfonyl) features, its overall solubility is a balancing act between these contrasting properties.
  • Temperature: Like many organic compounds, the solubility may increase with temperature, allowing it to dissolve more readily in common organic solvents.
  • Solvent Compatibility: Generally, it is more soluble in organic solvents such as ethyl acetate, methanol, and dimethyl sulfoxide (DMSO), but poorly soluble in water due to its non-polar characteristics.

In practical scenarios, it would be wise to consider utilizing solubility-enhancing techniques, particularly in pharmacological contexts, where bioavailability is a critical factor. As Charles Darwin once reflected, "It is not the strongest of the species that survive, nor the most intelligent, but the one most responsive to change." Similarly, understanding and optimizing the solubility of compounds like 2-ethylsulfonyl-2-(4-fluorophenyl)-2-phenyl-acetamide lends itself to their successful application in diverse fields.


Interesting facts

Interesting Facts about 2-Ethylsulfonyl-2-(4-fluorophenyl)-2-phenyl-acetamide

2-Ethylsulfonyl-2-(4-fluorophenyl)-2-phenyl-acetamide is a compound that showcases intriguing chemical characteristics and potential applications. Here are some fascinating insights about this compound:

  • Pharmacological Potential: This compound is of significant interest in the field of medicinal chemistry. Its unique structure may offer new avenues for drug development, particularly in targeting specific biological pathways.
  • Fluorinated Aromatics: The incorporation of the (4-fluorophenyl) group enhances its pharmacokinetic properties which can improve bioavailability and metabolic stability, making it a subject of research in pharmaceutical studies.
  • Ethylsulfonyl Group: The presence of the ethylsulfonyl moiety is noteworthy, as it can influence the compound's solubility and reactivity, potentially aiding in its efficacy as a therapeutic agent.
  • Potential Roles: Compounds like this one are often explored for their functions as:
    • Antimicrobial agents
    • Analgesics
    • Anti-inflammatory drugs
  • Structure-Activity Relationship (SAR): The structuring of the compound allows researchers to investigate the effects of various substituents on biological activity, contributing to the broader field of SAR studies.
  • Research Opportunities: Current research might focus on optimizing the compound’s properties for specific applications, providing valuable insights for future pharmacological innovations.

In summary, 2-ethylsulfonyl-2-(4-fluorophenyl)-2-phenyl-acetamide stands as a promising candidate for further studies and emphasizes the importance of exploring unique chemical structures in the continuous quest for effective therapeutic agents.

Synonyms
2-(Ethylsulfonyl)-2-(p-fluorophenyl)-2-phenylacetamide
14292-51-4
BRN 2156746
ACETAMIDE, 2-(ETHYLSULFONYL)-2-(p-FLUOROPHENYL)-2-PHENYL-
DTXSID40931682
2-(Ethanesulfonyl)-2-(4-fluorophenyl)-2-phenylethanimidic acid