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(±)-2-Fluoro-1-phenylethanol

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Identification
Molecular formula
C8H9FO
CAS number
403-42-9
IUPAC name
2-fluoro-1-phenyl-ethanol
State
State

At room temperature, 2-Fluoro-1-phenylethanol is in a liquid state. It is typically stored in sealed containers to maintain its stability and prevent it from absorbing moisture from the air or reacting with other substances.

Melting point (Celsius)
-27.00
Melting point (Kelvin)
246.15
Boiling point (Celsius)
110.00
Boiling point (Kelvin)
383.15
General information
Molecular weight
140.16g/mol
Molar mass
140.1550g/mol
Density
1.1257g/cm3
Appearence

2-Fluoro-1-phenylethanol appears as a clear liquid. It is often colorless or may have a slight pale yellow tint. The liquid is usually consistent and free from any suspensions or particulate matter.

Comment on solubility

Solubility of 2-fluoro-1-phenyl-ethanol

2-fluoro-1-phenyl-ethanol, a compound with both organic and inorganic characteristics, exhibits interesting solubility properties. Its solubility can be influenced by several factors:

  • Polarity: Due to the presence of a hydroxy group (-OH) and a fluorine atom, this compound is considered to be polar. This polar nature enhances its solubility in polar solvents such as water.
  • Hydrogen Bonding: The -OH group allows for hydrogen bonding with water, further increasing its solubility in aqueous solutions.
  • Organic Solvents: In non-polar organic solvents, the solubility may decrease significantly, as the polar functional groups are less compatible with non-polar environments.
  • Temperature Dependence: The solubility of 2-fluoro-1-phenyl-ethanol can also vary with temperature; typically, an increase in temperature will result in increased solubility in both polar and non-polar solvents.

It is essential to note that while 2-fluoro-1-phenyl-ethanol is soluble in water, the degree of solubility can vary based on the concentration and specific conditions of the solution.

Overall, the solubility characteristics of this compound make it intriguing for various applications, especially in areas where solvent interactions play a crucial role.

Interesting facts

Interesting Facts about 2-fluoro-1-phenyl-ethanol

The compound 2-fluoro-1-phenyl-ethanol is an intriguing example of a substituted alcohol, specifically featuring a fluorine atom bonded to a carbon adjacent to the hydroxyl group. This unique structure allows for a blend of interesting chemical properties and potential applications.

1. Chemical Structure and Properties

  • Fluorine Influence: The presence of a fluorine atom can significantly influence the reactivity and polarity of the compound.
  • Substituted Alcohol: As a substituted ethanol, this compound possesses both the hydroxyl (-OH) group characteristic of alcohols and the aromatic phenyl ring, which can affect its solubility and interaction with other substances.

2. Applications in Chemistry

  • Synthesis Route: 2-fluoro-1-phenyl-ethanol can serve as a precursor in the synthesis of various chemical compounds used in pharmaceuticals.
  • Research Applications: It is often studied for its potential in developing selective fluorinating agents and as a model compound in understanding the effects of fluorine substitution in organic chemistry.

3. Biological Activity

There is growing interest in the biological implications of compounds like 2-fluoro-1-phenyl-ethanol. Research indicates that fluorinated compounds can exhibit:

  • Enhanced Metabolic Stability: Fluorination may protect the compound from metabolic degradation.
  • Selective Bioactivity: Certain fluorinated compounds show unique interactions with biological targets, which can lead to innovations in drug design.

4. Safety Considerations

As with many chemical compounds, it is important to handle 2-fluoro-1-phenyl-ethanol with caution. Key safety measures include:

  • Using appropriate personal protective equipment (PPE) when handling the compound.
  • Understanding its toxicity profile and potential environmental impact.

In conclusion, 2-fluoro-1-phenyl-ethanol is more than just a chemical entity; it represents the intersection of structure, reactivity, and biological significance, making it a compelling study in the field of organic chemistry.

Synonyms
2-Fluoro-1-phenylethanol
450-94-2
2-FLUORO-1-PHENYLETHAN-1-OL
DTXSID50963318
1-Phenyl-2-fluoroethanol
alpha-Fluoromethylbenzyl alcohol
Ethanol, 2-fluoro-1-phenyl-
(1S)-2-fluoro-1-phenylethan-1-ol
MFCD01732759
Benzenemethanol, alpha-(fluoromethyl)-
BENZYL ALCOHOL, alpha-FLUOROMETHYL-
fluoromethylbenzyl alcohol
2-fluoro-1-phenyl-ethanol
SCHEMBL8375805
DTXCID601391078
KEA22974
EN300-1613241
877-779-6