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2-Fluoro-3-phenylpropanoic acid

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Identification
Molecular formula
C9H9FO2
CAS number
77352-99-5
IUPAC name
2-fluoro-3-phenyl-propanoic acid
State
State

At room temperature, 2-Fluoro-3-phenylpropanoic acid is in a solid state. This stability makes it easy to handle in experimental and chemical synthesis contexts. The crystalline nature also allows for precise measurement and handling, with low volatility reducing the risk of unwanted exposure.

Melting point (Celsius)
83.00
Melting point (Kelvin)
356.15
Boiling point (Celsius)
288.50
Boiling point (Kelvin)
561.70
General information
Molecular weight
168.17g/mol
Molar mass
168.1690g/mol
Density
1.2110g/cm3
Appearence

2-Fluoro-3-phenylpropanoic acid typically appears as a white to off-white crystalline powder. It is solid at room temperature, with a firm texture and a consistent color throughout. The compound's appearance might vary slightly depending on its purity and the specific conditions under which it is examined.

Comment on solubility

Solubility of 2-fluoro-3-phenyl-propanoic acid

2-fluoro-3-phenyl-propanoic acid, a carboxylic acid derivative, exhibits interesting solubility characteristics due to its molecular structure. The solubility of this compound can be influenced by various factors:

  • Polarity: The presence of a carboxylic acid functional group can lead to enhanced polarity, which typically increases solubility in polar solvents like water.
  • Hydrogen Bonding: The ability of the carboxylic group to form hydrogen bonds with water molecules allows for better solubility compared to non-polar compounds.
  • Fluorine Substitution: The 2-fluoro substitution can alter the electronic distribution within the molecule, potentially affecting its interaction with solvents.
  • Aromatic Influence: The phenyl group provides hydrophobic character, which might decrease solubility in highly polar solvents.

In general, 2-fluoro-3-phenyl-propanoic acid is expected to have moderate solubility in water, though solubility may decrease in non-polar organic solvents. It is this balance of polar and non-polar characteristics that defines its solubility profile.

Overall, understanding the solubility of 2-fluoro-3-phenyl-propanoic acid is essential for its practical applications in chemical processes and formulations.

Interesting facts

Interesting Facts About 2-fluoro-3-phenyl-propanoic acid

2-fluoro-3-phenyl-propanoic acid is a fascinating compound that showcases the intricate relationship between structure and function in organic chemistry. Here are some noteworthy aspects:

  • Chemical Structure: This compound features a remarkable combination of a fluoro group and a phenyl group, which can significantly influence its reactivity and interactions. The presence of the F atom can affect the acidity and strength of the compound due to its electronegativity.
  • Biological Activity: Compounds similar to 2-fluoro-3-phenyl-propanoic acid have been investigated for their potential as pharmaceuticals, particularly in the field of anti-inflammatory agents. The ability of this compound to mimic certain biological molecules can lead to interesting therapeutic applications.
  • Stereochemistry: The compound has stereocenters that may lead to different stereoisomers, each with distinct biological activities. Studying the effects of these isomers can provide insights into how small changes in molecular structure can lead to significant changes in function.
  • Synthetic Routes: The synthesis of 2-fluoro-3-phenyl-propanoic acid can serve as an excellent example for organic chemistry students. It allows for the exploration of various synthetic methods, including substitutions and functional group interconversions, making it a valuable learning platform.
  • Research Implications: Ongoing studies around this compound reveal its potential use in materials science, particularly in the design of novel polymers or as intermediates in organic synthesis.

In summary, 2-fluoro-3-phenyl-propanoic acid is more than just a simple chemical compound; it offers a treasure trove of opportunities for research and application across different fields in chemistry. Its unique configuration and biological potential make it an intriguing subject for further study.

Synonyms
2-fluoro-3-phenylpropanoic acid
457-45-4
Benzenepropanoic acid, a-fluoro-
DTXSID201307075
alpha-Fluorohydrocinnamic acid
NSC 84357
HYDROCINNAMIC ACID, alpha-FLUORO-
BRN 2362893
alpha-Fluorobenzenepropanoic acid
Benzenepropanoic acid, alpha-fluoro-
WLN: QVYF1R
4-09-00-01766 (Beilstein Handbook Reference)
SCHEMBL246475
2-fluoro-3-phenylpropanoicacid
.alpha.-Fluorohydrocinnamic acid
I+/--Fluorobenzenepropanoic acid
DTXCID801737022
AAA45745
NSC84357
CCG-40484
Hydrocinnamic acid, .alpha.-fluoro-
NSC-84357
AKOS017532213
Benzenepropanoic acid, .alpha.-fluoro-
CS-0232579
EN300-127676
F2147-5620
864-572-0