Skip to main content

2-fluoro-N-(1-naphthyl)acetamide

ADVERTISEMENT
Identification
Molecular formula
C12H10FNO
CAS number
76958-27-7
IUPAC name
2-fluoro-N-(1-naphthyl)acetamide
State
State

At room temperature, 2-fluoro-N-(1-naphthyl)acetamide is typically in a solid state, characterized by its crystalline structure.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
345.00
Boiling point (Kelvin)
618.15
General information
Molecular weight
215.22g/mol
Molar mass
215.2250g/mol
Density
1.2200g/cm3
Appearence

2-Fluoro-N-(1-naphthyl)acetamide appears as a white to off-white crystalline solid. It has a crystalline texture and is typically found in powdered form.

Comment on solubility

Solubility of 2-fluoro-N-(1-naphthyl)acetamide

When it comes to the solubility of 2-fluoro-N-(1-naphthyl)acetamide, several factors must be considered:

  • Polarity: The presence of the fluorine atom adds to the polarity of the molecule, potentially increasing its interaction with polar solvents.
  • Hydrophobic Character: The naphthyl moiety, being large and hydrophobic, can restrict solubility in aqueous environments.
  • Solvent Selection: It tends to have better solubility in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), or acetone due to the larger hydrophobic component.

In practical applications, the solubility of 2-fluoro-N-(1-naphthyl)acetamide might be characterized by:

  • Good solubility in organic solvents
  • Lesser solubility in water

As a general guideline, it is recommended to test solubility in various solvents to identify the most suitable conditions for its use in experiments or formulations. Understanding the solubility profile of this compound is crucial for optimizing its application in research and industry.

Interesting facts

Interesting Facts about 2-Fluoro-N-(1-naphthyl)acetamide

2-Fluoro-N-(1-naphthyl)acetamide, a compound belonging to the amide family, presents a fascinating blend of organic chemistry and practical applications. Here are some intriguing aspects of this chemical:

  • Fluorine Addition: The presence of a fluorine atom in the molecule significantly affects its chemical reactivity and properties. Fluorinated compounds often exhibit enhanced metabolic stability, making them valuable in pharmaceuticals.
  • Biological Significance: Amides, such as 2-Fluoro-N-(1-naphthyl)acetamide, play crucial roles in biological systems. Their structural configuration allows them to engage in various biochemical interactions, making them relevant in drug design and development.
  • Naphthyl Influence: The naphthyl group attached to the amide not only contributes to the compound's physical characteristics but also enhances π-π stacking interactions, which can influence biological activity and target specificity in drug formulations.
  • Research Applications: This compound has been of interest in medicinal chemistry for its potential therapeutic applications. Scientists often explore derivatives of such compounds for their efficacy against various diseases, particularly in the fight against cancer.
  • Mechanisms of Action: Investigating **mechanisms of action** involving 2-fluoro-N-(1-naphthyl)acetamide can yield critical insights into how differently structured amides interact within biological systems, potentially leading to novel treatments or enhancements in existing therapies.

In summary, 2-Fluoro-N-(1-naphthyl)acetamide is not just an inert chemical; it is a **dynamic compound** with a plethora of applications and implications in both research and industry. The ongoing study of its properties continues to intrigue chemists and biologists alike, paving the way for innovative discoveries.

Synonyms
318-85-4
ACETAMIDE, 2-FLUORO-N-(NAPHTHYL)-
2-Fluoro-N-1-naphthylacetamide
(1-Naphthyl) monofluoroacetamide
1-Naphthaleneacetamide, 2-fluoro-
BRN 2104632
DTXSID00185664
4-12-00-03023 (Beilstein Handbook Reference)
DTXCID40108155