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2-Fluoro-N-(1-naphthylmethyl)-N-phenylacetamide

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Identification
Molecular formula
C19H16FNO
CAS number
861556-18-1
IUPAC name
2-fluoro-N-(1-naphthylmethyl)-N-phenyl-acetamide
State
State
The compound is in a solid state at room temperature, characterized by its stable crystal form and negligible vapor pressure under standard conditions.
Melting point (Celsius)
142.00
Melting point (Kelvin)
415.15
Boiling point (Celsius)
403.20
Boiling point (Kelvin)
676.35
General information
Molecular weight
283.32g/mol
Molar mass
283.3150g/mol
Density
1.2350g/cm3
Appearence

The compound appears as a white solid at room temperature. Its crystalline form may vary based on synthesis methods, but generally, it is a powder or has a crystalline lattice structure.

Comment on solubility

Solubility of 2-fluoro-N-(1-naphthylmethyl)-N-phenyl-acetamide

The solubility of 2-fluoro-N-(1-naphthylmethyl)-N-phenyl-acetamide (C19H16FNO) can be quite intriguing due to its specific molecular structure and the functional groups present. Here are some key points to consider regarding its solubility:

  • Polar vs Nonpolar Solubility: The presence of the fluorine atom can introduce some polarity, but the overall structure is predominantly nonpolar due to the large nonpolar naphthyl and phenyl groups. This suggests limited solubility in polar solvents.
  • Common Solvents: It is anticipated that this compound will dissolve well in organic solvents such as ethanol, chloroform, or dimethyl sulfoxide (DMSO) which can stabilize the nonpolar regions of the molecule.
  • Temperature Effects: Like many organic compounds, solubility can increase with temperature. Thus, heating the solvent may facilitate the dissolution of the compound.
  • Hydrogen Bonding: The acetamide functional group could participate in hydrogen bonding networks when mixed with suitable solvents, potentially increasing solubility in solvents capable of hydrogen bonding.

In conclusion, the solubility of 2-fluoro-N-(1-naphthylmethyl)-N-phenyl-acetamide is largely influenced by its molecular characteristics, with a tendency towards better solubility in nonpolar organic solvents compared to polar solvents. Understanding these solubility behaviors is essential for potential applications in pharmaceuticals and materials science.

Interesting facts

Interesting Facts about 2-Fluoro-N-(1-naphthylmethyl)-N-phenyl-acetamide

2-Fluoro-N-(1-naphthylmethyl)-N-phenyl-acetamide is a fascinating compound that merges elements of medicinal chemistry and fluorine chemistry. Here are some compelling aspects of this compound:

  • Fluorine's Role: The presence of fluorine in this compound enhances its biological activity. Fluorinated compounds often display increased metabolic stability and lipophilicity, which are key attributes in drug development.
  • Structural Diversity: This compound features a unique structure containing a naphthyl group, which is well-known in the field of organic chemistry for contributing to the aromatic, stable nature of the compounds. Naphthalene derivatives have numerous applications in pharmaceuticals and dyes.
  • Regulatory Potential: The acetamide functional group offers potential in the synthesis of various biologically active molecules. Compounds like these are often investigated for their efficacy in treating conditions such as pain or inflammation.
  • Research Interest: With the rise of new therapies and the need for more effective drugs, there is ongoing research aimed at derivatives of this compound. The structural framework allows for modifications that may improve selectivity and reduce side effects.
  • Applications Beyond Medicine: Besides medicinal applications, compounds of this type are also explored in fields like materials science and agricultural chemistry, where their properties can lead to innovations in new materials or pest control solutions.

Overall, 2-Fluoro-N-(1-naphthylmethyl)-N-phenyl-acetamide serves as a prime example of how organic chemistry can intersect with real-world applications, opening doors for further exploration and study in various scientific domains.

Synonyms
BRN 2149420
2-Fluoro-N-(1-naphthylmethyl)acetanilide
ACETANILIDE, 2-FLUORO-N-(1-NAPHTHYLMETHYL)-
10016-05-4
DTXSID90142983
DTXCID6065474