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2-Fluoroethylamine

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Identification
Molecular formula
C4H9F2N
CAS number
930-24-1
IUPAC name
2-fluoro-N-(2-fluoroethyl)ethanamine
State
State

At room temperature, 2-Fluoroethylamine exists as a liquid. It is volatile and can emit fumes under standard conditions.

Melting point (Celsius)
-50.00
Melting point (Kelvin)
223.15
Boiling point (Celsius)
107.00
Boiling point (Kelvin)
380.15
General information
Molecular weight
79.08g/mol
Molar mass
79.0800g/mol
Density
0.9380g/cm3
Appearence

2-Fluoroethylamine is typically a clear, colorless liquid at room temperature. It is known to have an odor that can be described as fishy or ammonia-like.

Comment on solubility

Solubility of 2-fluoro-N-(2-fluoroethyl)ethanamine

2-fluoro-N-(2-fluoroethyl)ethanamine, a compound featuring fluorinated moieties, exhibits notable solubility characteristics that are influenced by its molecular structure. Here are some key points regarding its solubility:

  • Polarity: The presence of fluorine atoms typically increases polarity due to strong electronegativity, which often enhances solubility in polar solvents.
  • Hydrogen Bonding: The amine group (-NH2) allows for potential hydrogen bonding with water, further promoting solubility in aqueous environments.
  • Solvents: It is expected to be soluble in a variety of solvents, specifically polar solvents such as water and alcohols, while having lower solubility in non-polar solvents.
  • Temperature Dependence: Like many organic compounds, its solubility may improve at elevated temperatures, aiding in dissolution processes.

In summary, the solubility behavior of this compound is primarily dictated by its functional groups and the resulting interactions with solvent molecules. As a rule of thumb, more polar compounds tend to favor solubility in polar solvents. Given its unique structure, 2-fluoro-N-(2-fluoroethyl)ethanamine showcases a compelling solubility profile, making it an interesting subject for further exploration in chemical applications.

Interesting facts

Interesting Facts About 2-Fluoro-N-(2-fluoroethyl)ethanamine

2-Fluoro-N-(2-fluoroethyl)ethanamine is an intriguing compound that belongs to the class of amines, which are essential in both organic chemistry and biological processes. Here are some notable aspects of this compound:

  • Fluorine Substituents: The presence of fluorine in this compound is significant. Fluorinated compounds often exhibit unique properties that make them of interest in medicinal chemistry, such as improved metabolic stability and altered pharmacokinetics.
  • Potential Applications: Compounds like 2-fluoro-N-(2-fluoroethyl)ethanamine are under exploration for their utility in drug design, particularly in developing antidepressants and antipsychotic medications. The varying electron-withdrawing effects of fluorine can influence the compound's biological activity.
  • Synthesis Routes: The synthesis of this compound can involve several reactions, including nucleophilic substitution and functionalization of fluoroalkanes. Understanding these routes not only enhances synthetic chemistry skills but also opens avenues for creating novel compounds.
  • Structure-Activity Relationship (SAR): Studying this compound can lead to insights into the SAR of amines. By modifying the structure, researchers can evaluate how changes affect biological activity, which is crucial in drug development.
  • Environmental Impact: The stability and potential persistence of fluorinated compounds in the environment pose ecological questions. The study of such compounds can foster discussions on sustainability and environmental science.

In summary, 2-fluoro-N-(2-fluoroethyl)ethanamine showcases the intersection of chemistry with pharmacology and environmental science. Its unique properties attributed to fluorine substitutions make it a subject of continued research and interest!

Synonyms
Bis(2-fluoroethyl)amine
373-19-3
NCIOpen2_000637
SCHEMBL5110254
AKOS006346834
EN300-6450982