Skip to main content

Parafluoroanilide

ADVERTISEMENT
Identification
Molecular formula
C15H16FNO2
CAS number
1026281-53-4
IUPAC name
2-fluoro-N-(2-hydroxy-1-methyl-ethyl)-N-(1-naphthyl)acetamide
State
State

At room temperature, the compound is a crystalline solid. It is not hygroscopic and remains stable in the presence of atmospheric moisture. The stability and solid state make it suitable for a range of applications in organic synthesis and pharmaceuticals.

Melting point (Celsius)
72.50
Melting point (Kelvin)
345.65
Boiling point (Celsius)
368.50
Boiling point (Kelvin)
641.65
General information
Molecular weight
259.29g/mol
Molar mass
259.2930g/mol
Density
1.2400g/cm3
Appearence

The compound typically appears as a white to off-white crystalline solid with a mild aromatic odor. It is stable under normal conditions but should be stored in a cool, dry place. The crystalline texture ensures its easy handling and transportation in a laboratory setting.

Comment on solubility

Solubility of 2-fluoro-N-(2-hydroxy-1-methyl-ethyl)-N-(1-naphthyl)acetamide

The solubility of 2-fluoro-N-(2-hydroxy-1-methyl-ethyl)-N-(1-naphthyl)acetamide can be quite intriguing, given its complex structure. This compound, which features a mix of polar and non-polar functional groups, shows variability in solubility depending on the solvent used. Here are some key insights:

  • Polar Solvents: Due to the presence of the hydroxyl group, this compound is likely to exhibit moderate solubility in polar solvents like water and methanol.
  • Non-Polar Solvents: In non-polar solvents, such as hexane, solubility may be limited because of the compound’s naphthyl group, which is hydrophobic and tends to delocalize electrons.
  • Influential Factors: Factors that can influence solubility include temperature, pH, and the presence of other solutes, which may facilitate or hinder solubility.

As a general trend, compounds like 2-fluoro-N-(2-hydroxy-1-methyl-ethyl)-N-(1-naphthyl)acetamide with both hydrophilic and hydrophobic characteristics may lead to intricate solubility behavior, making solubility studies essential for applications in pharmacology and material science.

Interesting facts

Interesting Facts about 2-fluoro-N-(2-hydroxy-1-methyl-ethyl)-N-(1-naphthyl)acetamide

2-fluoro-N-(2-hydroxy-1-methyl-ethyl)-N-(1-naphthyl)acetamide is a fascinating compound with diverse implications in the field of medicinal chemistry. Here are some noteworthy aspects:

  • Pharmaceutical Potential: This compound is known for its interactions with various biological targets, making it a valuable candidate for drug development, particularly in the treatment of neurological disorders.
  • Fluorination Effects: The presence of a fluorine atom can significantly enhance the lipophilicity and metabolic stability of the compound, which may lead to improved pharmacokinetic properties.
  • Chirality: The compound’s configuration means it can exist in enantiomeric forms, which can exhibit different biological activities. This characteristic is especially crucial in drug design, where one enantiomer may be therapeutically beneficial while another could be inactive or even harmful.
  • Hydroxyl Group Influence: The hydroxyl (–OH) group contributes not only to the compound's solubility but also plays a role in binding interactions with biological molecules, enhancing its efficacy.
  • Structure-Activity Relationships (SAR): Understanding how changes in the compound's structure affect its biological activity is an essential area of study in medicinal chemistry. Researchers often explore variations in side chains to optimize therapeutic effects.

As you delve into the world of chemical compounds, remember that every unique structure has the potential to lead to groundbreaking discoveries, transforming our understanding of medicine and biochemistry!

Synonyms
10016-12-3
2-FLUORO-N-(1-HYDROXYPROPAN-2-YL)-N-(NAPHTHALEN-1-YL)ACETAMIDE
2-fluoro-N-(1-hydroxypropan-2-yl)-N-naphthalen-1-ylacetamide
2-Fluoro-N-(2-hydroxy-1-methylethyl)-N-(1-naphtyl)acetamide
BRN 2138832
DTXSID10905234
2-Fluoro-N-(2-hydroxy-1-methylethyl)-N-1-naphthylacetamide
ACETAMIDE, 2-FLUORO-N-(2-HYDROXY-1-METHYLETHYL)-N-1-NAPHTHYL-
Acetamide, 2-fluoro-N-(2-hydroxy-1-methylethyl)-N-1-naphthalenyl-