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Fluorofenidone

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Identification
Molecular formula
C14H14FNO2
CAS number
133627-45-9
IUPAC name
2-fluoro-N-(2-hydroxy-1-methyl-ethyl)-N-(2-naphthyl)acetamide
State
State

At room temperature, Fluorofenidone is in a solid state. It is often handled as a solid crystalline powder for ease of measurement and storage. The compound is stable under standard atmospheric conditions, maintaining its integrity without sublimation or decomposition.

Melting point (Celsius)
111.60
Melting point (Kelvin)
384.75
Boiling point (Celsius)
433.40
Boiling point (Kelvin)
706.55
General information
Molecular weight
285.31g/mol
Molar mass
285.3070g/mol
Density
1.2822g/cm3
Appearence

Fluorofenidone appears as a white crystalline powder. It is solid under standard conditions and can be received in a powdered form, which is typical for many pharmaceutical compounds. The crystalline nature may allow it to have a glossy or semi-glossy finish under certain lighting conditions.

Comment on solubility

Solubility of 2-fluoro-N-(2-hydroxy-1-methyl-ethyl)-N-(2-naphthyl)acetamide

The solubility of 2-fluoro-N-(2-hydroxy-1-methyl-ethyl)-N-(2-naphthyl)acetamide is quite intricate and can be influenced by various factors. Understanding its solubility is essential for applications in pharmaceuticals and research. Here are some key points to consider:

  • Polarity: The presence of the hydroxyl group in the molecular structure enhances the polarity of the compound, which may increase its solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl group can engage in hydrogen bonding, contributing to its potential solubility. This interaction can facilitate dissolution in water.
  • Hydrophobic Character: The naphthyl moiety may impart some hydrophobic characteristics, possibly decreasing solubility in aqueous environments.
  • Solvent Selection: This compound may exhibit better solubility in organic solvents, especially those that can interact with aromatic rings or can accommodate hydrophobic regions.
  • Environmental Factors: Temperature and pH may also impact solubility, altering how the compound interacts with solvents.

In summary, while 2-fluoro-N-(2-hydroxy-1-methyl-ethyl)-N-(2-naphthyl)acetamide has features that could promote increased solubility in certain environments, its overall behavior in solution will depend on the balance between its polar and nonpolar characteristics. As always, empirical solubility tests are recommended to gain precise insight into its behavior under specific conditions.

Interesting facts

Interesting Facts about 2-fluoro-N-(2-hydroxy-1-methyl-ethyl)-N-(2-naphthyl)acetamide

This compound, known for its complex structure and unique chemical properties, belongs to a fascinating class of compounds that engage chemists and researchers alike. Its structural elements create opportunities for various applications, especially in medicinal chemistry.

Unique Structural Features

The presence of the fluorine atom significantly enhances the compound's biological activity and lipophilicity, making it a candidate for drug development. Moreover, the incorporation of the naphthyl group contributes to its aromatic stability and potential interactions with biological targets.

Potential Applications

  • Pharmaceutical Research: The compound's structure suggests it may exhibit properties suitable for therapeutic applications.
  • Biological Activity: The hydroxyl group enhances its interaction with biological systems, making it a subject of interest in studies related to enzyme inhibition.

Scientific Implications

2-fluoro-N-(2-hydroxy-1-methyl-ethyl)-N-(2-naphthyl)acetamide may play a role in the exploration of structure-activity relationships (SAR) in drug design, helping scientists better understand how modifications in chemical structures can influence biological effects. Understanding these relationships is crucial for developing more effective and targeted therapies.

Quote to Remember

As one renowned chemist once said, "The magic of chemistry lies in its ability to transform simple molecules into complex medicines that heal and save lives." This compound exemplifies that magic, illustrating the importance of chemical modifications in creating innovative therapeutic agents.

Synonyms
10016-15-6
2-Fluoro-N-(2-hydroxy-1-methylethyl)-N-2-naphthylacetamide
BRN 2138825
ACETAMIDE, 2-FLUORO-N-(2-HYDROXY-1-METHYLETHYL)-N-2-NAPHTHYL-
DTXSID70905235
2-FLUORO-N-(1-HYDROXYPROPAN-2-YL)-N-(NAPHTHALEN-2-YL)ACETAMIDE