Skip to main content

Fluoroacetamide

ADVERTISEMENT
Identification
Molecular formula
C2H4FNO
CAS number
640-19-7
IUPAC name
2-fluoro-N-(2-hydroxyethyl)-N-(1-naphthyl)acetamide
State
State

At room temperature, Fluoroacetamide is typically in a solid state. It is known for maintaining its stability in its solid form under standard environmental conditions.

Melting point (Celsius)
116.00
Melting point (Kelvin)
389.20
Boiling point (Celsius)
178.70
Boiling point (Kelvin)
451.80
General information
Molecular weight
109.04g/mol
Molar mass
109.0400g/mol
Density
1.2630g/cm3
Appearence

Fluoroacetamide appears as a white crystalline solid. It is characterized by its pure white color and crystalline structure, making it visually distinct in its solid state.

Comment on solubility

Solubility of 2-fluoro-N-(2-hydroxyethyl)-N-(1-naphthyl)acetamide

The solubility of 2-fluoro-N-(2-hydroxyethyl)-N-(1-naphthyl)acetamide (C2H4FNO) can be influenced by several factors due to its unique structural attributes. Generally, it exhibits varying levels of solubility in different solvents, which is crucial for its application in various chemical processes.

Key Points on Solubility:

  • Polarity: The presence of the hydroxy group (-OH) significantly increases the polar character of the compound, making it more soluble in polar solvents like water.
  • Hydrophobic Interactions: The naphthyl group contributes hydrophobic characteristics, which might reduce solubility in purely polar solvents, yet enhance solubility in organic solvents such as ethanol or acetone.
  • Temperature Effects: As with many organic compounds, solubility may increase with temperature. Higher temperatures can break intermolecular forces that could otherwise hinder solubility.
  • pH Influence: The ionization of the hydroxy and amine functional groups can also influence solubility in aqueous environments, where changes in pH may affect the protonation state of the molecule.

Understanding these factors assists researchers and formulators in predicting how this compound will behave in various environments, and aids in developing effective applications.

Interesting facts

Interesting Facts about 2-Fluoro-N-(2-hydroxyethyl)-N-(1-naphthyl)acetamide

2-Fluoro-N-(2-hydroxyethyl)-N-(1-naphthyl)acetamide is a fascinating compound that highlights the intricate interplay between chemistry and pharmacology. Here are some intriguing aspects:

  • Unique Structure: This compound features a distinctive combination of a fluorine atom, a hydroxyl group, and a naphthalene moiety, contributing to its interesting chemical behavior and potential biological activity.
  • Potential Biological Activity: Compounds like this one, which possess both aromatic and hydrophilic features, are often assessed for their drug-like properties. The presence of the naphthyl group suggests it may have applications in medicinal chemistry.
  • Fluorine’s Influence: The incorporation of fluorine into organic compounds can significantly affect their reactivity, solubility, and interaction with biological systems, making it a valuable element in drug design.
  • Hydroxyl Group: The hydroxyl group can enhance the solubility of the compound in biological systems, potentially leading to improved pharmacokinetics in therapeutic applications.
  • Research Applications: Scientists are currently exploring structures similar to this compound in the search for new anti-cancer agents and other pharmaceuticals.

In summary, 2-fluoro-N-(2-hydroxyethyl)-N-(1-naphthyl)acetamide stands as a promising candidate in the fields of medicinal chemistry and chemical biology. Its complex structure and the strategic incorporation of fluorine and hydroxyl functionalities make it an exciting subject for further research and discovery. As researchers delve deeper into its properties, it could lead to significant advancements in drug formulation.

Synonyms
10016-11-2
BRN 2133859
2-Fluoro-N-(2-hydroxyethyl)-N-1-naphthylacetamide
ACETAMIDE, 2-FLUORO-N-(2-HYDROXYETHYL)-N-1-NAPHTHYL-
DTXSID50142989
DTXCID0065480
2-fluoro-N-(2-hydroxyethyl)-N-naphthalen-1-ylacetamide
2-Fluoro-N-(2-Hydroxyethyl)-N-(1-Naphtyl)Acetamide