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2-fluoro-N-(2-pyridyl)acetamide

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Identification
Molecular formula
C7H7FN2O
CAS number
3988-24-7
IUPAC name
2-fluoro-N-(2-pyridyl)acetamide
State
State

At room temperature, 2-fluoro-N-(2-pyridyl)acetamide is in a solid state.

Melting point (Celsius)
122.00
Melting point (Kelvin)
395.15
Boiling point (Celsius)
402.00
Boiling point (Kelvin)
675.15
General information
Molecular weight
154.15g/mol
Molar mass
154.1480g/mol
Density
1.2850g/cm3
Appearence

2-Fluoro-N-(2-pyridyl)acetamide typically appears as a crystalline solid with a white to off-white color.

Comment on solubility

Solubility of 2-fluoro-N-(2-pyridyl)acetamide

The solubility of 2-fluoro-N-(2-pyridyl)acetamide is an important aspect to consider in both its application and behavior in various environments. As a member of the amide family, this compound exhibits unique solubility characteristics influenced by its molecular structure.

Key Points on Solubility:

  • Polarity: The presence of the fluorine atom and the pyridine ring contributes to the overall polarity of the molecule, which plays a crucial role in its solubility in polar solvents, such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to the amide functional group enhances its solubility in polar solvents. Consequently, it may readily dissolve in organic solvents such as alcohols and DMSO.
  • Temperature Dependency: Like many organic compounds, the solubility of 2-fluoro-N-(2-pyridyl)acetamide can vary significantly with temperature. Generally, an increase in temperature leads to enhanced solubility.
  • pH Influence: The solubility can also be affected by pH levels. In acidic conditions, the compound may protonate, altering its solubility profile compared to neutral or basic environments.

In summary, the solubility of 2-fluoro-N-(2-pyridyl)acetamide is primarily dictated by its polar nature and ability to form hydrogen bonds, making it soluble in polar organic solvents. Understanding these solubility characteristics is essential for its use in various chemical processes and applications.

Interesting facts

Interesting Facts about 2-Fluoro-N-(2-Pyridyl)acetamide

2-Fluoro-N-(2-pyridyl)acetamide is a fascinating compound that belongs to the class of amides, which are organic compounds characterized by the presence of a carbonyl group (C=O) linked to a nitrogen atom. Here are some intriguing aspects about this compound:

  • Structure and Function: The compound features a fluorine atom substituting a hydrogen atom on the acetamide portion, which can significantly influence its chemical reactivity and interaction with biological systems.
  • Biological Significance: Compounds containing fluorine are often studied for their pharmaceutical potential. The presence of the pyridyl group can enhance the compound's interaction with biological targets, making it a candidate for drug development.
  • Research Applications: This compound is of great interest in organic synthesis and medicinal chemistry, where modifications can lead to the discovery of new therapeutic agents.
  • Potential Uses: As with many fluorinated compounds, it is hypothesized that 2-fluoro-N-(2-pyridyl)acetamide may exhibit properties such as increased metabolic stability and enhanced efficacy compared to its non-fluorinated analogs.

As scientists delve into the world of fluorinated compounds, 2-fluoro-N-(2-pyridyl)acetamide stands out as a promising molecule. Its unique structural characteristics not only make it an interesting subject of study but also highlight the importance of fluorine chemistry in developing novel compounds with enhanced biological activity.

Synonyms
2-Fluoro-N-(2-pyridyl)acetamide
457-43-2
BRN 0128960
N-(alpha-Pyridyl)fluoroacetamide
Pyridine, 2-(2-fluoroacetamido)-
Acetamide, 2-fluoro-N-2-pyridinyl-
ACETAMIDE, 2-FLUORO-N-(2-PYRIDYL)-
DTXSID00963424
2-Fluoro-N-(pyridin-2-yl)ethanimidic acid
4-22-00-03880 (Beilstein Handbook Reference)