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2-Fluoro-N-(3-nitrophenyl)acetamide

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Identification
Molecular formula
C8H7FN2O3
CAS number
21828-54-6
IUPAC name
2-fluoro-N-(3-nitrophenyl)acetamide
State
State

At room temperature, 2-Fluoro-N-(3-nitrophenyl)acetamide is in a solid state. It maintains its structural integrity below its melting point and should be handled as a fine powder solid, which suggests proper protective measures to prevent inhalation and contact.

Melting point (Celsius)
90.50
Melting point (Kelvin)
363.65
Boiling point (Celsius)
365.00
Boiling point (Kelvin)
638.15
General information
Molecular weight
198.15g/mol
Molar mass
198.1460g/mol
Density
1.3855g/cm3
Appearence

2-Fluoro-N-(3-nitrophenyl)acetamide is typically found as a crystalline solid. It appears as an off-white powder and may possess subtle yellowish hues depending on impurities. The compound exhibits a high degree of homogeneity once purified.

Comment on solubility

Solubility of 2-fluoro-N-(3-nitrophenyl)acetamide

When it comes to the solubility of 2-fluoro-N-(3-nitrophenyl)acetamide, it showcases interesting characteristics worth noting:

  • Polarity: The presence of the nitro group and the amide functional group contributes to the compound's polarity, which can enhance its solubility in polar solvents.
  • Solvent Types: This compound is likely to be more soluble in:
    • Polar solvents (e.g., water, methanol)
    • Protic solvents due to the ability to form hydrogen bonds
  • Hydrogen Bonding: The amide group can engage in hydrogen bonding with solvent molecules, further promoting solubility.

However, the extent of solubility can vary significantly based on factors such as temperature and pH of the solution. The addition of 2-fluoro may also influence the compound's overall reactivity and interaction with other molecules.

In conclusion, while exact solubility data may be scarce, it can be inferred that 2-fluoro-N-(3-nitrophenyl)acetamide is likely to demonstrate reasonable solubility in polar environments, owing to its structural features and functional groups.

Interesting facts

Interesting Facts about 2-Fluoro-N-(3-nitrophenyl)acetamide

2-Fluoro-N-(3-nitrophenyl)acetamide is a fascinating compound that exhibits a range of intriguing properties and applications in scientific research and industry. Here are some noteworthy aspects of this compound:

  • Pharmacological Relevance: This compound is essential in the field of medicinal chemistry due to its potential as a pharmaceutical agent. Its structure suggests that it may interact with biological targets, making it a candidate for drug development.
  • Fluorine's Influence: The presence of the fluorine atom in its structure often enhances the compound's *lipophilicity*, which is key in improving bioavailability and pharmacokinetic profiles of drugs.
  • Nitro Group Implications: The 3-nitrophenyl moiety can influence the compound's reactivity and properties. Nitro groups are known for their ability to stabilize carbanions and enhance aromatic substitution reactions, which are vital in synthetic pathways.
  • Research Utility: Researchers often use compounds like 2-fluoro-N-(3-nitrophenyl)acetamide as intermediates to synthesize more complex molecules, showcasing its versatility in organic synthesis.
  • Potential Toxicology Studies: Understandably, the interactions of such compounds with biological systems are a topic of ongoing research, especially considering the nitro group, which requires careful assessment for potential toxicity.

As a compound with *dual reactivity*, 2-fluoro-N-(3-nitrophenyl)acetamide serves as a perfect example of how small modifications can lead to dramatically different attributes and applications in the world of chemistry. The ongoing exploration of its properties and mechanisms is enabling scientists to unpack further potential uses in various fields, from synthetic chemistry to pharmacology.

Synonyms
2-Fluoro-3'-nitroacetanilide
ACETANILIDE, 2-FLUORO-3'-NITRO-
3435-76-5
BRN 2114849
DTXSID40187925
DTXCID00110416
SCHEMBL9427754