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Fluoride

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Identification
Molecular formula
C9H9F2NO
CAS number
101668-68-4
IUPAC name
2-fluoro-N-(4-fluorophenyl)-N-methyl-acetamide
State
State

At room temperature, the compound exists in a solid state, forming crystalline structures typical of many organic amides.

Melting point (Celsius)
52.00
Melting point (Kelvin)
325.15
Boiling point (Celsius)
274.00
Boiling point (Kelvin)
547.15
General information
Molecular weight
185.17g/mol
Molar mass
185.1740g/mol
Density
1.1810g/cm3
Appearence

The compound is typically a white to off-white crystalline solid. Its physical appearance can be influenced by purity and form.

Comment on solubility

Solubility of 2-fluoro-N-(4-fluorophenyl)-N-methyl-acetamide

The solubility characteristics of 2-fluoro-N-(4-fluorophenyl)-N-methyl-acetamide can be quite intriguing due to its unique structure. This compound presents both polar and nonpolar functional groups, which can lead to variable interactions with solvents. Here are some key points to consider:

  • Polar Aspects: The presence of the amide functional group (-C(=O)NH-) enhances its ability to engage in hydrogen bonding. This often results in improved solubility in polar solvents such as water and alcohols.
  • Nonpolar Aspects: The fluorophenyl ring adds some hydrophobic character, which may limit solubility in highly polar solvents. These nonpolar interactions can enhance solubility in organic solvents like dichloromethane and ethyl acetate.
  • General Solubility Trend: Generally, compounds like this one show better solubility in mixtures of polar and nonpolar solvents, revealing a **balance** that must be struck based on the solvent choice.
  • Temperature and Concentration Effects: Precise solubility can be influenced by temperature — typically, increasing the temperature enhances solubility. However, significant solubility data specific to 2-fluoro-N-(4-fluorophenyl)-N-methyl-acetamide may be limited.

In summary, while 2-fluoro-N-(4-fluorophenyl)-N-methyl-acetamide demonstrates potential for solubility in various solvents, its solubility profile is likely contingent upon the specific conditions of the solution and the nature of the solvent. Always consider the solvent interactions and the structural features of the compound for effective solubility assessments.

Interesting facts

Interesting Facts about 2-Fluoro-N-(4-fluorophenyl)-N-methyl-acetamide

2-Fluoro-N-(4-fluorophenyl)-N-methyl-acetamide is an intriguing compound in the world of organic chemistry, with several noteworthy characteristics:

  • Pharmaceutical Relevance: This compound belongs to a class of fluorinated organic compounds that are often explored for their potential roles in medicinal chemistry. Fluorine substitution can significantly impact the biological activity of compounds, making this a point of interest for drug development.
  • Fluorine Effects: The presence of two fluorine atoms introduces unique properties, such as enhanced metabolic stability and lipophilicity, which can affect how drugs behave in biological systems. Compounds containing fluorine often exhibit improved pharmacokinetic profiles compared to their non-fluorinated counterparts.
  • Applications in Research: Scientists are continually investigating the effects of fluorinated compounds in various fields, including agrochemistry and materials science. The specific structural features of this compound make it a candidate for studies looking into its potential as an agrochemical or in the synthesis of complex organic molecules.
  • Synthetic Routes: The synthesis of 2-fluoro-N-(4-fluorophenyl)-N-methyl-acetamide provides a practical platform for demonstrating various organic reactions, such as nucleophilic substitutions and acylation processes, making it a valuable teaching tool in advanced organic chemistry courses.

Overall, 2-Fluoro-N-(4-fluorophenyl)-N-methyl-acetamide encapsulates the fascinating interplay of structure and function in organic chemistry. As chemists explore its diverse applications, they unveil the myriad ways in which seemingly simple modifications can lead to profound changes in molecular behavior and functionality.

Synonyms
10016-06-5
ACETANILIDE, 2,4'-DIFLUORO-N-METHYL-
2,4'-Difluoro-N-methylacetanilide
BRN 2102024
DTXSID50142984
DTXCID1065475
2-fluoro-N-(4-fluorophenyl)-N-methylacetamide