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2-Fluoro-N-(4-fluorophenyl)acetamide

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Identification
Molecular formula
C8H7F2NO
CAS number
179898-16-3
IUPAC name
2-fluoro-N-(4-fluorophenyl)acetamide
State
State

At room temperature, 2-Fluoro-N-(4-fluorophenyl)acetamide is in the solid state. This is typical for many organic amides with similar molecular weights.

Melting point (Celsius)
118.00
Melting point (Kelvin)
391.20
Boiling point (Celsius)
308.40
Boiling point (Kelvin)
581.50
General information
Molecular weight
185.15g/mol
Molar mass
185.1660g/mol
Density
1.3623g/cm3
Appearence

2-Fluoro-N-(4-fluorophenyl)acetamide is a solid compound that typically appears as a white or off-white crystalline material. This appearance is common in compounds where phenyl groups are present, alongside amide functionalities.

Comment on solubility

Solubility of 2-fluoro-N-(4-fluorophenyl)acetamide

The solubility of 2-fluoro-N-(4-fluorophenyl)acetamide can be characterized by its interactions with various solvents. As a compound with both polar and non-polar functional groups, it exhibits a unique solubility profile:

  • Polar Solvents: Typically, compounds containing amide groups, like this one, tend to dissolve well in polar solvents such as water and alcohols due to their capacity for hydrogen bonding.
  • Non-Polar Solvents: The presence of aromatic rings suggests solubility in organic solvents like benzene or toluene, allowing for diverse applications in organic synthesis.
  • Influence of Fluorine Atoms: The fluorine substituents can enhance polarity, thus potentially improving solubility in polar environments while also affecting the intermolecular interactions.

However, the exact solubility can vary significantly based on factors such as:

  1. Temperature: Higher temperatures often increase solubility.
  2. pH Levels: Changes in pH can alter the degree of ionization, affecting solubility.
  3. Concentration: Solubility limits may dictate practical applications in laboratory settings.

In conclusion, while 2-fluoro-N-(4-fluorophenyl)acetamide is expected to be soluble in various solvents, the precise solubility characteristics are influenced by its structural attributes and environmental conditions. As with many organic compounds, it's always advisable to conduct experimental solubility tests for accurate data.

Interesting facts

Interesting Facts about 2-Fluoro-N-(4-fluorophenyl)acetamide

2-Fluoro-N-(4-fluorophenyl)acetamide is a fascinating compound that is gaining attention in the fields of medicinal chemistry and pharmacology. Here are some key points to consider:

  • Fluorine's Role: The presence of fluorine atoms in this compound plays a critical role in modifying its biological properties. Fluorination can enhance metabolic stability and increase lipophilicity, which makes fluorinated compounds a staple in drug design.
  • Potential Therapeutic Applications: Research suggests that compounds similar to 2-fluoro-N-(4-fluorophenyl)acetamide may have potential uses in treating various diseases, particularly those related to neurodegeneration and cancer. The specific arrangement of its atoms helps in engaging with biological targets effectively.
  • Structure-Activity Relationship: Understanding this compound deepens our insights into structure-activity relationships (SAR) in pharmaceuticals. Scientists can modify certain elements to optimize effectiveness and minimize side effects.
  • Significance of Acetamides: Acetamides, the class into which this compound falls, are widely studied due to their versatility and presence in a range of pharmaceutical agents. They often demonstrate fascinating interactions with biological receptors.
  • Research Interest: Ongoing studies are dedicated to exploring the interactions of 2-fluoro-N-(4-fluorophenyl)acetamide with enzymes and proteins, enhancing our understanding of its mechanisms of action.

As a scientist or chemistry student, exploring this compound opens a window into advanced chemical synthesis and the potential for developing new pharmaceutical agents. Researchers are continuously inspired by the *interplay of halogenation* and *functionalization*, leading to innovative discoveries in the world of chemistry.

Synonyms
ACETANILIDE, 2,4'-DIFLUORO-
404-42-2
2,4'-Difluoroacetanilide
BRN 2091568
SCHEMBL9843748
DTXSID60193402