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2-Fluoro-N-(4-methoxyphenyl)acetamide

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Identification
Molecular formula
C9H10FNO2
CAS number
450-91-9
IUPAC name
2-fluoro-N-(4-methoxyphenyl)acetamide
State
State

At room temperature, 2-Fluoro-N-(4-methoxyphenyl)acetamide is a solid. It maintains its solid state under usual room conditions, making it manageable for various synthetic and analytical applications where a stable solid compound is needed.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
292.00
Boiling point (Kelvin)
565.15
General information
Molecular weight
183.18g/mol
Molar mass
183.1760g/mol
Density
1.2803g/cm3
Appearence

2-Fluoro-N-(4-methoxyphenyl)acetamide is typically seen as a white to off-white crystalline solid. Its crystalline nature reflects its well-organized molecular structure, which is common among small organic amide compounds.

Comment on solubility

Solubility of 2-fluoro-N-(4-methoxyphenyl)acetamide

The solubility of 2-fluoro-N-(4-methoxyphenyl)acetamide can be influenced by several factors, making it an interesting compound to study. Here are some key considerations:

  • Polarity: The presence of both a fluoro group and a methoxy group contributes to the overall polarity of the molecule. Generally, compounds with higher polarity tend to be more soluble in polar solvents like water.
  • Hydrogen Bonding: The amide functional group can engage in hydrogen bonding, which might enhance its solubility in polar solvents. The ability to form such interactions is crucial for solubility.
  • Solvent Type: It is essential to consider the solvent when discussing solubility. For example, 2-fluoro-N-(4-methoxyphenyl)acetamide may exhibit good solubility in organic solvents such as ethanol or methanol, while its solubility in water could be limited.
  • Temperature Influence: As with many organic compounds, increasing temperature can often increase solubility. However, the specific solubility trend for this particular compound should be verified experimentally.

In summary, while 2-fluoro-N-(4-methoxyphenyl)acetamide may have some solubility in various solvents, the extent of this solubility will depend on factors like polarity, solvent choice, and temperature. Understanding these characteristics is essential for applications in chemical synthesis and pharmaceutical development.

Interesting facts

Interesting Facts about 2-Fluoro-N-(4-methoxyphenyl)acetamide

2-Fluoro-N-(4-methoxyphenyl)acetamide is a fascinating compound with a variety of intriguing characteristics and potential applications. Here are some notable points to consider:

  • Fluorine in Focus: The presence of a fluorine atom in this compound significantly alters its biological and chemical properties. Fluorine often enhances the compound's lipophilicity, making it more efficient in crossing biological membranes.
  • Pharmacological Potential: Compounds with similar structures have been researched for their pharmacological activity. These compounds can exhibit properties such as anti-inflammatory, analgesic, or even anticancer activities, highlighting the importance of this specific modification.
  • Structure-Activity Relationship (SAR): The introduction of methoxy and fluoro groups in the aromatic ring allows for detailed studies in SAR. Understanding how different substituents influence biological activity can lead to the development of more effective therapeutic agents.
  • Applications in Medicinal Chemistry: 2-Fluoro-N-(4-methoxyphenyl)acetamide could play a role in the development of new drugs, especially in the treatment of diseases where standard therapies fail. Researchers often capitalize on the unique properties of fluorinated compounds.

In conclusion, 2-fluoro-N-(4-methoxyphenyl)acetamide combines the intriguing aspects of fluorine substitution with distinct functionalities contributed by the methoxy group. As the field of medicinal chemistry continues to evolve, compounds like this one may provide the bridge to groundbreaking therapeutic innovations.

Synonyms
p-ACETANISIDIDE, 2-FLUORO-
332-35-4
2-Fluoro-p-acetanisidide
BRN 2642779
DTXSID70186845