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2-Fluoro-N-(4-nitrophenyl)acetamide

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Identification
Molecular formula
C8H7FN2O3
CAS number
64084-83-1
IUPAC name
2-fluoro-N-(4-nitrophenyl)acetamide
State
State

At room temperature, 2-fluoro-N-(4-nitrophenyl)acetamide is found in a solid state.

Melting point (Celsius)
170.00
Melting point (Kelvin)
443.15
Boiling point (Celsius)
327.30
Boiling point (Kelvin)
600.45
General information
Molecular weight
200.15g/mol
Molar mass
200.1520g/mol
Density
1.4980g/cm3
Appearence

2-Fluoro-N-(4-nitrophenyl)acetamide appears as a crystalline solid. It is typically characterized by its off-white to light yellow coloration.

Comment on solubility

Solubility of 2-fluoro-N-(4-nitrophenyl)acetamide

The solubility of 2-fluoro-N-(4-nitrophenyl)acetamide can be described as follows:

  • Polarity: This compound has both polar and nonpolar characteristics, which influences its solubility.
  • Solvent Compatibility: It is likely to be soluble in polar solvents, such as:
    • Water
    • Dimethyl sulfoxide (DMSO)
    • Acetonitrile
  • Temperature Dependency: Like many organic compounds, solubility can increase with temperature. Thus, heating a solution might enhance its solubilization.
  • Interactions: The presence of the nitro group (-NO2) and the fluorine atom (-F) can create strong dipole-dipole interactions with the solvent, potentially increasing solubility.

In summary, the solubility of 2-fluoro-N-(4-nitrophenyl)acetamide is influenced by its structural characteristics, polarity, and the type of solvent used. As such, understanding these factors can aid chemists in predicting and optimizing its solubility for various applications.

Interesting facts

Interesting Facts about 2-fluoro-N-(4-nitrophenyl)acetamide

2-fluoro-N-(4-nitrophenyl)acetamide is a fascinating compound with unique chemical properties and potential applications. Here are some intriguing insights:

  • Structure and Composition: This compound features a fluorine atom attached to a nitrogen-containing acetamide, providing it with distinctive reactivity. The presence of both the nitro group and the fluoro substituent results in interesting electronic effects that can significantly influence the compound's behavior in chemical reactions.
  • Applications in Drug Design: Compounds like 2-fluoro-N-(4-nitrophenyl)acetamide are often explored in the field of medicinal chemistry. The substitution patterns can impact drug efficacy, making it a valuable candidate for developing new pharmaceuticals, particularly in targeting specific biological pathways.
  • Environmental Chemistry: The nitro group is known for its potential environmental persistence. Thus, studying the stability and degradation of this compound in environmental conditions can inform regulatory policies and safe usage practices.
  • Mechanistic Studies: Its unique structure allows scientists to explore various reaction mechanisms. Researchers can investigate how the electron-withdrawing properties of the nitro and fluoro groups influence nucleophilic attacks or other chemical transformations.
  • Analytical Techniques: This compound can be assessed using a range of analytical chemistry methods such as NMR spectroscopy, mass spectrometry, and chromatography, allowing chemists to discern its purity and structural characteristics.

In conclusion, 2-fluoro-N-(4-nitrophenyl)acetamide is more than just a chemical entity; its intriguing properties and applications illustrate the dynamic nature of chemistry and its relevance in modern science.

Synonyms
ACETANILIDE, 2-FLUORO-4'-NITRO-
2-Fluoro-4'-nitroacetanilide
370-89-8
NSC 403007
BRN 2114837
DTXSID00190495
4-12-00-01632 (Beilstein Handbook Reference)
NSC-403007
2-fluoro-N-(4-nitrophenyl)acetamide
NSC403007
p-Nitro-2-fluoroacetanilide
27PUG933XK
SCHEMBL8462705
DTXCID10112986
2-Fluoro-N-(p-nitrophenyl)acetamide
Acetamide, 2-fluoro-N-(4-nitrophenyl)-