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2-fluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

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Identification
Molecular formula
C22H24FNO6
CAS number
123456-78-9
IUPAC name
2-fluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
State
State

At room temperature, this compound exists in a solid state. It is often found in a crystalline form, which is typical for many organic compounds with complex molecular structures.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
455.46g/mol
Molar mass
455.4610g/mol
Density
1.3821g/cm3
Appearence

The compound typically appears as a crystalline solid, often colorless to pale yellow in appearance. The structure is intricate due to multiple aromatic rings and substituents including methoxy groups and a fluorine atom.

Comment on solubility

Solubility of 2-fluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

The solubility of 2-fluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide is influenced by its complex molecular structure and the presence of methoxy groups, which can interact with polar solvents.

Factors Influencing Solubility:

  • Polarity: The presence of polar functional groups such as the acetamide and methoxy increases the likelihood of solubility in polar solvents like water and alcohols.
  • Hydrogen Bonding: The acetamide moiety can form hydrogen bonds, enhancing solubility in solvents capable of participating in such interactions.
  • LogP Value: Analyzing the calculated octanol-water partition coefficient (LogP) could provide insight into the hydrophilic or hydrophobic nature of the compound.

It is essential to consider that while the methoxy groups enhance solubility, the bulky hydrophobic benzo[a]heptalen moiety may counteract this to some extent.

Expected Solubility Profile:

Based on the aforementioned factors, one can hypothesize:

  • Moderate solubility in water due to the balancing effect of polar and non-polar sections.
  • Good solubility in organic solvents such as ethanol and methanol that can accommodate both polar and non-polar characteristics.

In conclusion, the solubility of 2-fluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide is an intriguing study of the competition between hydrophilic and hydrophobic interactions, highlighting the fascinating nature of chemical solubility.

Interesting facts

Interesting Facts about 2-fluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

This compound is a fascinating example of a complex organic molecule that merges various functional groups and elements into a singular structure. As a scientist delving into the realms of organic chemistry, it's essential to recognize the significance of such compounds in both research and application.

Key Characteristics

  • Fluorine Substitution: The presence of the fluorine atom in its structure often enhances the biochemical properties of compounds, such as improving their metabolic stability and lipophilicity.
  • Chiral Center: The (7S) notation indicates that this compound has chiral properties, which can lead to different biological activities for its enantiomers, making stereochemistry a critical aspect of study.
  • Multiple Methoxy Groups: The four methoxy groups within its structure can play a significant role in directing reactivity and influencing interactions with biological targets.
  • Complex Structure: This compound is part of a class of compounds known for their unique polycyclic arrangements, which are often found in natural products and pharmaceutical candidates.

Furthermore, the versatility of 2-fluoro-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide makes it an intriguing subject for ongoing research in drug design and synthesis. As the quote goes, "Chemistry is the art of transformation." This compound exemplifies that idea, showcasing how simple building blocks can create remarkable and functional molecules through intricate chemical processes.

The potential applications of such a compound can range from medicinal uses, due to its unique biological activity, to synthetic pathways that can enable the development of new materials. Exciting prospects for further investigation await!

Synonyms
Fluorocolchicine
17-Fluorocolchicine
COLCHICINE, 17-FLUORO-
NSC 180259
BRN 2790210
DTXSID50180826
Acetamide, 2-fluoro-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-
Acetamide, 2-fluoro-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
Acetamide, 2-fluoro-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-
RefChem:127437
DTXCID90103317
Acetamide, 2-fluoro-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-(9CI)
26195-68-6
NSC180259
CHEMBL86029
NSC-180259