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2-fluoro-N-methyl-N-(1-naphthyl)acetamide

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Identification
Molecular formula
C13H12FNO
CAS number
1147722-06-1
IUPAC name
2-fluoro-N-methyl-N-(1-naphthyl)acetamide
State
State

At room temperature, 2-fluoro-N-methyl-N-(1-naphthyl)acetamide is found in a solid state. This is typical for many crystalline organic compounds of comparable molar mass.

Melting point (Celsius)
78.50
Melting point (Kelvin)
351.70
Boiling point (Celsius)
286.20
Boiling point (Kelvin)
559.30
General information
Molecular weight
221.25g/mol
Molar mass
221.2470g/mol
Density
1.2084g/cm3
Appearence

2-Fluoro-N-methyl-N-(1-naphthyl)acetamide is typically a white to off-white crystalline solid. Its crystalline structure contributes to its solid state at room temperature.

Comment on solubility

Solubility of 2-fluoro-N-methyl-N-(1-naphthyl)acetamide

The solubility of 2-fluoro-N-methyl-N-(1-naphthyl)acetamide can be quite nuanced due to its chemical structure. This compound features a combination of polar and nonpolar characteristics, which significantly influence its interaction with solvents. Here are some key points regarding its solubility:

  • Polar Nature: The presence of the acetamide group contributes to some degree of polarity, which may enhance its solubility in polar solvents such as water and alcohols.
  • Nonpolar Characteristics: The naphthyl ring, being a large hydrophobic structure, tends to decrease overall solubility in highly polar environments, suggesting that the compound may be more soluble in organic solvents like dichloromethane or ethanol.
  • Temperature Effects: Temperature variations can play a role in solubility; increased temperature often aids in dissolving organic compounds, providing better solvation of the constituent parts.
  • pH Sensitivity: The solubility can also be affected by the pH of the solution, as changes in acidity can influence the ionization states of the functional groups present.

In conclusion, while 2-fluoro-N-methyl-N-(1-naphthyl)acetamide is expected to have some solubility in polar solvents, its overall solubility is largely dependent on the solvent type, temperature, and pH levels. This behavior reflects the intricate balance of its chemical properties and interactions.

Interesting facts

Interesting Facts about 2-Fluoro-N-methyl-N-(1-naphthyl)acetamide

2-Fluoro-N-methyl-N-(1-naphthyl)acetamide is a fascinating compound that showcases the diverse world of organic chemistry. This compound falls under the category of amides, which are known for their roles in biological processes, pharmaceuticals, and material science. Here are some intriguing insights about this compound:

  • Fluorine's Influence: The incorporation of a fluorine atom into the molecular structure can significantly enhance the compound's reactivity and bioactivity. Fluorinated compounds often exhibit unique properties, which can lead to new applications in drug design.
  • Structural Significance: The naphthyl group in the compound contributes to its aromatic properties, which can affect its interaction with biological systems. The ability to form π-π interactions can enhance binding affinity with target biomolecules.
  • Medicinal Chemistry: Compounds similar to this one may act as crucial intermediates in synthesizing pharmaceuticals. They can be designed to target specific receptors, making them candidates for drug development.
  • Research Potential: Research into compounds like 2-fluoro-N-methyl-N-(1-naphthyl)acetamide is vital for understanding the full scope of their biological activity and therapeutic potential.

As a scientist or a chemistry student, recognizing the importance of functional groups and molecular structure in determining chemical behavior is essential. This compound exemplifies how subtle changes at the molecular level can create significant differences in reactivity and functionality. The use of fluorinated compounds has transformed many fields including medicinal chemistry, making all fluorinated derivatives worthy of study.


Synonyms
Nissol
5903-13-9
Nissol EC
ADL8ZU8B4W
NA-26
DP X 1410
ENT 27403
1-(N-Acetamidofluoromethyl)-naphthalene
BRN 2214468
N-Methyl-N-(1-naphthyl)fluoroacetamide
n-Methyl-n-(1-naphthyl)-fluoroacetamide
N-Methyl-N-1-naftylfluoracetamid [Czech]
N-Methyl-N-(1-naphthyl)monofluoroacetamide
N-Methyl-N-1-naftylfluoracetamid
N-methyl-N-1-naphthyl-2-fluoroacetamide
MNAF
MNFA
Acetamide, 2-fluoro-N-methyl-N-1-naphthalenyl-
2-Fluoro-N-methyl-N-1-naphthylacetamide
2-Fluoro-N-methyl-N-1-naphthalenylacetamide
2-fluoro-N-methyl-N-naphthalen-1-ylacetamide
2-Fluoro-N-methyl-N-(naphthalen-1-yl)acetamide
ACETAMIDE, 2-FLUORO-N-METHYL-N-(1-NAPHTHYL)-
2-FLUORO-N-METHYL-N-NAPHTHALEN-1-YL-ACETAMIDE
UNII-ADL8ZU8B4W
methyl naphthyl fluoroacetamide
SCHEMBL435250
DTXSID1058139
N-Methyl-N-1-naphthyl acetamide
ADRPZEYTIFWCBC-UHFFFAOYSA-N
DB-293075
NS00133961