Skip to main content

2-Fluoro-N-methyl-N-(2-naphthyl)acetamide

ADVERTISEMENT
Identification
Molecular formula
C13H12FNO
CAS number
54231-32-4
IUPAC name
2-fluoro-N-methyl-N-(2-naphthyl)acetamide
State
State

At room temperature, 2-Fluoro-N-methyl-N-(2-naphthyl)acetamide exists in a solid state, typically as a crystalline powder. It is stable under normal conditions and does not easily react with other compounds without the application of external energy or catalysts.

Melting point (Celsius)
124.50
Melting point (Kelvin)
397.65
Boiling point (Celsius)
354.50
Boiling point (Kelvin)
627.65
General information
Molecular weight
215.24g/mol
Molar mass
215.2370g/mol
Density
1.2200g/cm3
Appearence

2-Fluoro-N-methyl-N-(2-naphthyl)acetamide is a crystalline solid. The compound typically appears as a white or off-white, fine powder. Its crystalline form tends to reflect light, giving it a slightly shiny or lustrous look.

Comment on solubility

Solubility of 2-fluoro-N-methyl-N-(2-naphthyl)acetamide

The solubility of 2-fluoro-N-methyl-N-(2-naphthyl)acetamide (C13H12FNO) is influenced by several factors, including its molecular structure and intermolecular interactions. Here are some key points regarding its solubility:

  • Polarity: The presence of the fluorine atom and the amide functional group contributes to the compound's polarity, which can affect its solubility in polar solvents.
  • Solvent Compatibility: 2-fluoro-N-methyl-N-(2-naphthyl)acetamide is likely to be more soluble in organic solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Ethyl acetate
    • Methanol
  • Water Solubility: Given its hydrophobic naphthalene structure, this compound is expected to have limited solubility in water, making it more soluble in non-polar solvents.
  • Temperature Effects: As with many compounds, an increase in temperature may enhance solubility due to increased molecular motion.

As a general guideline, the statement "like dissolves like" is crucial when predicting the solubility of compounds. Since 2-fluoro-N-methyl-N-(2-naphthyl)acetamide has both polar and non-polar characteristics, the choice of solvent becomes important for achieving satisfactory solubility. Understanding these interactions can assist chemists in effectively utilizing this compound in various applications.

Interesting facts

Interesting Facts about 2-Fluoro-N-methyl-N-(2-naphthyl)acetamide

2-Fluoro-N-methyl-N-(2-naphthyl)acetamide is a fascinating compound that captures the interest of many chemists due to its unique structure and potential applications. Here are some intriguing points about this compound:

  • Fluorine Influence: The presence of a fluorine atom significantly alters the reactivity and properties of this acetamide. Fluorine's electronegativity can enhance the compound's pharmacological efficacy, making it an intriguing subject for medicinal chemistry.
  • Role in Pharmaceuticals: Compounds featuring naphthalene derivatives are often explored for their therapeutic potential. They may exhibit activities such as anti-inflammatory, anticancer, or analgesic effects. Researchers are continually investigating derivative compounds for their medicinal uses.
  • Synthetic Versatility: 2-Fluoro-N-methyl-N-(2-naphthyl)acetamide is often employed as a building block in synthetic organic chemistry. Its functional groups allow for various chemical transformations, facilitating the creation of more complex organic molecules.
  • Structural Considerations: The naphthalene ring system contributes to the compound's aromaticity, lending stability and influencing its interaction with biological receptors. Studying how this structure interacts at the molecular level can reveal insights into its potential effects.
  • Research Potential: Given the ongoing interest in fluoro-organic compounds in drug design, this specific acetamide may inspire further research. Scientists are keen to explore its mechanisms of action and optimize its properties for targeted applications.

In summary, 2-fluoro-N-methyl-N-(2-naphthyl)acetamide stands out due to its unique chemical characteristics and promising pathways in medicinal chemistry and synthetic applications. Its study could lead to new breakthroughs in drug development and organic synthesis.

Synonyms
10016-14-5
BRN 2213187
ACETAMIDE, 2-FLUORO-N-METHYL-N-2-NAPHTHYL-
2-Fluoro-N-methyl-N-2-naphthylacetamide
DTXSID20142991
DTXCID0065482
2-fluoro-N-methyl-N-naphthalen-2-ylacetamide
2-Fluoro-N-methyl-N-(2-naphtyl)acetamide