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2-Fluoro-N-(p-tolyl)acetamide

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Identification
Molecular formula
C9H10FNO
CAS number
455-34-3
IUPAC name
2-fluoro-N-(p-tolyl)acetamide
State
State
Solid at room temperature, usually in the form of a crystalline powder.
Melting point (Celsius)
136.00
Melting point (Kelvin)
409.15
Boiling point (Celsius)
274.20
Boiling point (Kelvin)
547.40
General information
Molecular weight
165.18g/mol
Molar mass
165.1780g/mol
Density
1.1695g/cm3
Appearence

2-Fluoro-N-(p-tolyl)acetamide appears as a white to off-white crystalline solid. It is typically in a powder form, lacking any specific distinguishable odor.

Comment on solubility

Solubility of 2-fluoro-N-(p-tolyl)acetamide

The solubility of 2-fluoro-N-(p-tolyl)acetamide can be influenced by various factors, including its molecular structure and the presence of polar and non-polar functional groups. This compound exhibits unique solubility characteristics that merit attention:

  • Polar Character: The presence of the amide group contributes to some polar behavior, potentially allowing for solubility in polar solvents like water.
  • Non-Polar Influence: The p-tolyl group is largely non-polar, which may lead to limited solubility in highly polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds can enhance solubility in alcohols and some organic solvents.
  • Temperature Effects: Solubility may increase with temperature, as is common with many organic compounds.

In conclusion, while 2-fluoro-N-(p-tolyl)acetamide may have moderate solubility in certain polar solvents, the balance of its functional groups suggests that the solubility could be limited in highly polar environments. As always, it is recommended to conduct experimental solubility tests to accurately determine the compound's behavior in various solvents.

Interesting facts

Interesting Facts about 2-fluoro-N-(p-tolyl)acetamide

2-fluoro-N-(p-tolyl)acetamide is a fascinating compound that belongs to the class of amides, distinguished by its unique functionalities and potential applications. Here are some intriguing insights about this compound:

  • Relationship with Fluorine: The presence of a fluorine atom significantly influences the compound’s properties, such as its reactivity and lipophilicity. Fluorine atoms often enhance the biological activity of pharmaceuticals, making this compound noteworthy in medicinal chemistry.
  • Therapeutic Potential: Compounds similar to 2-fluoro-N-(p-tolyl)acetamide have been studied for their prospective roles in developing therapeutic agents. The modification of acetamides can lead to molecules with enhanced efficacy against various diseases.
  • Industrial Significance: This compound may find utility in the synthesis of agrochemicals, enhancing crop protection. Its unique chemical properties could be crucial in designing more effective herbicides or fungicides.
  • Structure-Activity Relationship (SAR): The study of 2-fluoro-N-(p-tolyl)acetamide provides a valuable insight into how structural modifications can affect biological activity, an essential aspect of drug design.
  • Research Opportunities: Ongoing research may explore the interaction of this compound with various biological targets, paving the way for breakthrough discoveries in pharmacology.

Understanding compounds like 2-fluoro-N-(p-tolyl)acetamide not only enhances our knowledge of organic chemistry but also opens doors to numerous applications that can impact health and industry. As we delve deeper into its properties and potential uses, we may uncover even more exciting possibilities.

Synonyms
2-Fluoro-p-acetotoluidide
p-ACETOTOLUIDIDE, 2-FLUORO-
BRN 2717562
Acetamide, 2-fluoro-N-(4-methylphenyl)-
404-40-0
DTXSID40193400
4-12-00-01903 (Beilstein Handbook Reference)
SCHEMBL715695
DTXCID10115891