Skip to main content

2-Fluoro-N-phenylacetamide

ADVERTISEMENT
Identification
Molecular formula
C8H8FNO
CAS number
451-81-0
IUPAC name
2-fluoro-N-phenyl-acetamide
State
State

At room temperature, 2-Fluoro-N-phenylacetamide is typically found in a solid crystalline state.

Melting point (Celsius)
111.00
Melting point (Kelvin)
384.15
Boiling point (Celsius)
305.00
Boiling point (Kelvin)
578.15
General information
Molecular weight
153.16g/mol
Molar mass
153.1560g/mol
Density
1.2210g/cm3
Appearence

2-Fluoro-N-phenylacetamide is a white crystalline solid. It is known for its slightly aromatic odor and is commonly found in the form of fine, shiny crystals or powder.

Comment on solubility

Solubility of 2-fluoro-N-phenyl-acetamide

2-fluoro-N-phenyl-acetamide (C9H10FNO) exhibits interesting solubility characteristics that are worth noting. Here are some key points:

  • Polarity: The presence of the fluoro group enhances the polarity of this compound, which can influence its solubility in various solvents.
  • Solvent Interaction: Generally, 2-fluoro-N-phenyl-acetamide is soluble in polar solvents such as water and methanol, due to hydrogen bonding capabilities with the solvent.
  • Organic Solvent Compatibility: It also shows good solubility in organic solvents like ethanol, dimethyl sulfoxide (DMSO), and acetone.
  • Insolubility Considerations: However, it may have limited solubility in non-polar solvents such as hexane or benzene, which lack the ability to engage in significant hydrogen bonding or dipole-dipole interactions.

The solubility profile of 2-fluoro-N-phenyl-acetamide may be influenced by factors such as temperature and the presence of other substances in the solution. Understanding its solubility can aid in applications involving synthesis and formulation in both pharmaceutical and chemical industries.

Interesting facts

Interesting Facts about 2-Fluoro-N-phenyl-acetamide

2-Fluoro-N-phenyl-acetamide is a fascinating compound that belongs to the family of acylamides. Here are some intriguing aspects of this compound that might capture the attention of chemists and students alike:

  • Fluorine Influence: The presence of a fluoro group significantly impacts the reactivity and biological properties of the molecule. Fluorine atoms often enhance the lipophilicity of compounds, making them more effective in interacting with biological targets.
  • Pharmaceutical Potential: Acetamides are commonly researched for their potential pharmaceutical applications. Several derivatives of this compound have been studied for their use in medicinal chemistry, especially in the development of analgesics and anti-inflammatory drugs.
  • Substituent Effects: The position of the substituent on the aromatic ring can lead to diverse properties. The para and meta positions, which differ in electron-donating or withdrawing nature, can significantly sway the biological activity and effect of the compound.
  • Research Interest: Studies have shown that compounds that incorporate fluorine and amide functional groups may exhibit interesting interactions in molecular biology, making them valuable in drug discovery and development frameworks.
  • synthetic versatility: This compound can be used as a building block in various synthetic pathways, allowing for the creation of more complex organic structures useful in both material science and pharmaceuticals.

In conclusion, 2-fluoro-N-phenyl-acetamide exemplifies the intricate relationship between structure and function in organic chemistry. As scientists continue to explore the nuances of fluorinated compounds, this molecule provides a remarkable case study in the potential of chemical innovation.

Synonyms
2-Fluoroacetanilide
2-Fluoro-N-phenylacetamide
330-68-7
Acetamide, 2-fluoro-N-phenyl-
Fluoroacetanilide
TL 1312
ACETANILIDE, 2-FLUORO-
AFL 1082
Anilid kyseliny fluoroctove
2-FLUOROACETANILINE
Fluoracetanilid
Anilid kyseliny fluoroctove [Czech]
BRN 2085851
.alpha.-Fluoroacetanilide
SCHEMBL2781923
DTXSID60870524
DB-347049