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2-Fluoroacetonitrile

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Identification
Molecular formula
C2H2FN
CAS number
503-17-3
IUPAC name
2-fluoroacetonitrile
State
State

At room temperature, 2-fluoroacetonitrile exists as a liquid. Due to its volatility, it can also exist in gaseous form if not properly contained in a sealed environment.

Melting point (Celsius)
-85.00
Melting point (Kelvin)
188.15
Boiling point (Celsius)
63.10
Boiling point (Kelvin)
336.25
General information
Molecular weight
57.05g/mol
Molar mass
57.0530g/mol
Density
1.0835g/cm3
Appearence

2-Fluoroacetonitrile is a clear, colorless liquid with a faint, pungent odor, similar to other nitriles. It is highly volatile and readily evaporates at room temperature, making its gaseous form and liquid form both significant under ambient conditions.

Comment on solubility

Solubility of 2-fluoroacetonitrile

2-fluoroacetonitrile, with the chemical formula C2H2F1N1, exhibits distinctive solubility characteristics in various solvents. Understanding its solubility profile is crucial for applications in organic synthesis and pharmaceutical development.

Solubility Characteristics:

  • Polar Solvents: 2-fluoroacetonitrile is well soluble in polar solvents such as water and alcohols due to its polar functional groups.
  • Non-Polar Solvents: While it is less soluble in non-polar solvents like hexane and benzene, it can still dissolve to some extent.
  • Temperature Dependence: Solubility can increase with temperature, making heat a useful factor to consider in dissolving this compound.
  • Hydrogen Bonding: The presence of hydrogen bonding capability can enhance its solubility in protic solvents.

In practical terms, when working with 2-fluoroacetonitrile, one might say, "It dissolves readily in polar environments," which highlights the importance of choosing the right solvent for effective utilization. Understanding these solubility traits allows chemists to optimize reactions and formulations involving this compound.

Interesting facts

Interesting Facts about 2-Fluoroacetonitrile

2-Fluoroacetonitrile is a fascinating compound that presents a unique intersection of organic chemistry and industrial application. Here are some intriguing insights:

  • Versatile Building Block: 2-Fluoroacetonitrile is used as a crucial building block in the synthesis of various fluorinated compounds. Fluorinated compounds are essential for numerous applications, including pharmaceuticals, agrochemicals, and specialty materials.
  • Fluorine’s Role: The presence of fluorine in its structure significantly alters the properties of 2-fluoroacetonitrile. Fluorine increases the compound's stability and lipophilicity, making it an excellent candidate in drug design and development.
  • Application in Drug Synthesis: In the medicinal chemistry domain, this compound serves as a starting material for the synthesis of fluorinated amino acids and other bioactive molecules, which can potentially lead to the discovery of new therapeutic agents.
  • Environmental Impact: While 2-fluoroacetonitrile has useful applications, it is essential for chemists to consider its environmental impact. As a nitrile compound, it is important to manage its use and disposal to minimize any potential ecological harm.
  • Research Interest: The compound has garnered attention in scientific research due to its reactivity and the role it plays in various chemical reactions, including nucleophilic substitutions and addition reactions.

Overall, 2-fluoroacetonitrile exemplifies the fascinating balance between utility and responsibility in the world of chemical compounds. As chemists continue exploring its potential, the future looks promising for this intriguing molecule!

Synonyms
Fluoroacetonitrile
503-20-8
ACETONITRILE, FLUORO-
Fluoromethyl cyanide
Monofluoroacetonitrile
BRN 1697891
DTXSID10198301
DTXCID00120792
610-523-1
2-fluoroacetonitrile
C2H2FN
fluoro-acetonitrile
MFCD00009969
2-fluoro-acetonitrile
FCH2CN
Fluoroacetonitrile, 98%
AKOS005258231
InChI=1/C2H2FN/c3-1-2-4/h1H
DB-007519
F0665
NS00121657
A20122
P18220