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2-Fluoroacetyl chloride

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Identification
Molecular formula
C2H2ClFO
CAS number
298-36-2
IUPAC name
2-fluoroacetyl chloride
State
State

At room temperature, 2-fluoroacetyl chloride exists as a liquid. It is typically stored under an inert atmosphere to prevent its highly reactive nature from causing unwanted reactions with moisture or other compounds.

Melting point (Celsius)
-114.00
Melting point (Kelvin)
159.15
Boiling point (Celsius)
104.00
Boiling point (Kelvin)
377.15
General information
Molecular weight
94.50g/mol
Molar mass
94.4990g/mol
Density
1.3250g/cm3
Appearence

2-Fluoroacetyl chloride is a colorless to pale yellow liquid. It may release pungent fumes when exposed to air due to its reactivity, making it a compound that often requires careful handling under controlled laboratory conditions.

Comment on solubility

Solubility of 2-Fluoroacetyl Chloride

2-Fluoroacetyl chloride, with the chemical formula C2H2ClFO, exhibits notable solubility characteristics that are integral to its applications in organic synthesis. Its solubility profile can be summarized as follows:

  • Solvent Compatibility: 2-Fluoroacetyl chloride is highly soluble in organic solvents such as dichloromethane, ether, and acetone.
  • Water Solubility: This compound is hydrolytically unstable in the presence of water, leading to its decomposition rather than simple dissolution. Thus, it is considered insoluble in water.
  • Temperature Sensitivity: Its solubility may increase with temperature, particularly in organic media.

Due to these solubility characteristics, 2-fluoroacetyl chloride is often utilized in reactions that take place under controlled conditions, where organic solvents are prevalent. As a general observation, the reactivity of acid chlorides with nucleophiles is a significant aspect of their uses, highlighting their behavior in solution.


Interesting facts

Interesting Facts about 2-Fluoroacetyl Chloride

2-Fluoroacetyl chloride is a fascinating compound that plays a significant role in various chemical processes and applications. Here are some noteworthy points about this compound:

  • Reactivity: 2-Fluoroacetyl chloride is highly reactive, primarily due to the presence of both the carbonyl group and the chlorinated acyl moiety. This makes it an ideal candidate for acylation reactions.
  • Precursor Molecule: It is often used as a precursor for synthesizing fluorinated compounds, which can exhibit unique physical and chemical properties compared to their non-fluorinated analogs.
  • Pharmaceutical Applications: The derivatives of 2-fluoroacetyl chloride have found utility in pharmaceutical research, particularly in the development of new medications targeting various biological pathways.
  • Synthesis of Heterocycles: This compound can be involved in the synthesis of heterocycles, which are crucial components in the design of modern drugs and agrochemicals.
  • Importance of Fluorine: The incorporation of fluorine into organic molecules often enhances their metabolic stability, which makes them more effective as therapeutic agents.

In summary, 2-fluoroacetyl chloride is more than just a chemical compound; it is a vital ingredient in the toolkit of chemists, paving the way for innovative developments in both pharmaceuticals and materials science. As scientists continue to explore its potentials, we might uncover even more applications that leverage its unique properties.

Synonyms
FLUOROACETYL CHLORIDE
2-fluoroacetyl chloride
359-06-8
Acetyl chloride, fluoro-
HSDB 6327
UNII-0CQX1ANG4H
0CQX1ANG4H
Chlorid kyseliny fluoroctove
Chlorid kyseliny fluoroctove [Czech]
EINECS 206-623-6
Acetyl chloride, 2-fluoro-
TL 670
BRN 1739051
DTXSID4059885
FLUOROACETYL CHLORIDE [HSDB]
Fluoroacetylchloride
fluoracetyl chloride
MFCD00015738
Acetyl chloride, fluoro
DTXCID4039104
AKOS015853783
FF104355
DB-007520
NS00041407
Q1434179
206-623-6