Skip to main content

2-Fluoroaniline

ADVERTISEMENT
Identification
Molecular formula
C6H6FN
CAS number
348-54-9
IUPAC name
2-fluoroaniline
State
State

2-Fluoroaniline is a liquid at room temperature. It is used in various chemical synthesis and can be hazardous upon exposure.

Melting point (Celsius)
-19.00
Melting point (Kelvin)
254.15
Boiling point (Celsius)
184.00
Boiling point (Kelvin)
457.15
General information
Molecular weight
111.13g/mol
Molar mass
111.1260g/mol
Density
1.1630g/cm3
Appearence

2-Fluoroaniline appears as a colorless to pale yellow liquid. It may darken with exposure to air and light. It has a distinct aromatic odor typical of anilines.

Comment on solubility

Solubility of 2-Fluoroaniline

2-Fluoroaniline, with the chemical formula C6H6F1N1, exhibits specific solubility characteristics that are important for its applications in chemical synthesis and industrial processes. Understanding the solubility behavior of this compound can be crucial for various practical uses.

Solubility Characteristics:

  • Polar Nature: The presence of the amino group (–NH2) and the fluorine atom contributes to its polar character, enhancing its interaction with polar solvents.
  • Solvent Compatibility: 2-Fluoroaniline is generally soluble in common polar solvents such as water, ethanol, and acetone, primarily due to hydrogen bonding capabilities.
  • Limited Solubility in Non-Polar Solvents: Conversely, this compound exhibits limited solubility in non-polar solvents like hexane or chloroform, reflecting its hydrophilic nature.

In summary, the solubility of 2-fluoroaniline is predominantly influenced by its molecular structure. As it can readily dissolve in polar solvents while struggling in non-polar environments, it is essential to choose the right solvent for desired chemical reactions and applications.


Interesting facts

Interesting Facts about 2-Fluoroaniline

2-Fluoroaniline, a compound known for its unique chemical properties, offers a fascinating glimpse into the world of aromatic amines. This compound has garnered interest in various fields, particularly in the synthesis of pharmaceuticals and agrochemicals.

Key Characteristics:

  • Substituted Aromatic Compound: The presence of the fluorine atom on the aniline structure significantly enhances the compound's reactivity, providing unique pathways for chemical transformations.
  • Importance in Synthesis: 2-Fluoroaniline is often used as a building block in organic synthesis, leading to the formation of more complex molecules. This makes it invaluable in drug design and industrial chemistry.
  • Biological Relevance: Compounds containing aniline derivatives, including 2-fluoroaniline, have been studied for their biological activities, including antimicrobial and anticancer properties.
  • Environmental Considerations: As with many fluorinated compounds, considerations about the environmental impact and toxicity of 2-fluoroaniline have been raised. Understanding its fate in biological and ecological systems is crucial.

Applications:

In the realm of applied science, 2-fluoroaniline plays a vital role in:

  • **Pharmaceuticals:** It is a key intermediate in the synthesis of drug candidates, illustrating the compound's potential in medicinal chemistry.
  • **Dye Manufacturing:** The compound contributes to the production of azo dyes and pigments, showcasing its versatility.
  • **Agricultural Chemicals:** Research into its efficacy in developing agrochemicals highlights its relevance in enhancing crop protection.

“The utility of 2-fluoroaniline in diverse applications underscores the beauty of chemistry in merging theoretical understanding with practical innovations.”

In summary, 2-fluoroaniline is more than just a simple chemical compound; it embodies the intricate relationships between molecular structure and function, making it a topic worthy of exploration for both students and seasoned chemists alike.

Synonyms
2-FLUOROANILINE
348-54-9
o-Fluoroaniline
1-Amino-2-fluorobenzene
Benzenamine, 2-fluoro-
2-Fluorobenzenamine
2-Fluoro-phenylamine
Aniline, o-fluoro-
2-fluorophenylamine
o-aminofluorobenzene
Aniline, 2-fluoro-
CHEBI:27526
SE32ZK6617
EINECS 206-478-9
MFCD00007642
NSC 10299
NSC-10299
UNII-SE32ZK6617
AI3-52644
CHEMBL195328
DTXSID8059843
UN 2941
2-fluoro-benzenamine
oFluoroaniline
2fluoroaniline
2-flouroaniline
Aniline, ofluoro
2-fluoro aniline
2-fluoro-aniline
2Fluorobenzenamine
2Fluorophenylamine
1lgw
2-Fluoroaniline-
Ortho-fluoroaniline
2-fluorobenzeneamine
1Amino2fluorobenzene
2-fluorobenzenaminium
Benzenamine, 2fluoro
(2-fluorophenyl)amine
1,2-fluorobenzenamine
(2-fluorophenyl)-amine
Aniline, ofluoro (8CI)
bmse000724
Aniline, o-fluoro-(8CI)
2-Fluoroaniline, >=99%
SCHEMBL33295
BIDD:GT0093
DTXCID1038905
CS-M2715
NSC10299
STR00771
BDBM50167958
STK802386
AKOS000118879
CCG-302491
DB02403
FF15645
1AN
o-Fluoroaniline; 1-Amino-2-fluorobenzene
PD008363
DB-028080
A6120
F0032
NS00041421
EN300-19550
AG-617/02198032
o-Fluoroaniline [UN2941] [Keep away from food]
Q27093404
F2190-0425
Z104474198
206-478-9