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2-Fluorobenzoyl chloride

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Identification
Molecular formula
C7H4ClFO
CAS number
393-52-2
IUPAC name
2-fluorobenzoyl chloride
State
State

2-Fluorobenzoyl chloride is typically a liquid at room temperature.

Melting point (Celsius)
-2.00
Melting point (Kelvin)
271.15
Boiling point (Celsius)
197.00
Boiling point (Kelvin)
470.15
General information
Molecular weight
158.55g/mol
Molar mass
158.5540g/mol
Density
1.3380g/cm3
Appearence

2-Fluorobenzoyl chloride is a colorless to light yellow liquid with a pungent odor. It is a corrosive compound that can fume in moist air, indicating its reactivity with water.

Comment on solubility

Solubility of 2-Fluorobenzoyl Chloride

2-Fluorobenzoyl chloride, with the chemical formula C7H4ClFO, exhibits specific solubility characteristics that are important to consider when handling and utilizing this compound. The solubility of this compound can be summarized as follows:

  • Solvent Compatibility: 2-Fluorobenzoyl chloride is generally soluble in organic solvents such as ether, acetone, and chloroform.
  • Water Solubility: This compound is insoluble in water, which is a significant property since it influences how the compound should be handled and disposed of.
  • Temperature Effect: The solubility may vary with temperature, generally increasing in higher temperatures for organic solvents.

It’s important to note that the presence of the chlorine and fluorine substituents can affect the polarity of the molecule, thus influencing its interactions with solvents. As a consequence, proper solvent choice is key for applications involving 2-fluorobenzoyl chloride, particularly in reactions and extractions.

In summary, handling 2-fluorobenzoyl chloride requires an understanding of its solubility behaviors, especially regarding its compatibility with organic solvents and its insolubility in water, which could potentially dictate the methodology of its application.

Interesting facts

Interesting Facts about 2-Fluorobenzoyl Chloride

2-Fluorobenzoyl chloride is a fascinating compound used widely in the field of organic chemistry and has several applications in the synthesis of various chemicals. Here are some compelling points about this compound:

  • Functional Group: It features a carbonyl group attached to a benzene ring substituted with a fluorine atom. This unique structure enables it to act as an important intermediate in many synthetic pathways.
  • Reactivity: As an acyl chloride, 2-fluorobenzoyl chloride is highly reactive. It can undergo several chemical reactions, including nucleophilic substitution and acylation, making it a valuable building block in the synthesis of pharmaceuticals and agrochemicals.
  • Fluorine's Influence: The presence of the fluorine atom often enhances the compound’s reactivity and stability. Fluorinated compounds are of particular interest in medicinal chemistry because they can improve the bioavailability and metabolic stability of drugs.
  • Applications: This compound is primarily used in the production of fluorinated organic molecules, which can lead to the development of new materials or pharmaceuticals with enhanced properties.

In the words of chemists, "Fluorine is not just an element; it’s a game-changer in molecular design." With its unique reactivity and the ability to influence physical and chemical properties significantly, 2-fluorobenzoyl chloride serves as a prime example of how small changes in molecular structure can lead to large impacts in scientific research and industry.

Synonyms
2-FLUOROBENZOYL CHLORIDE
393-52-2
o-Fluorobenzoyl chloride
Benzoyl chloride, 2-fluoro-
Benzoyl chloride, o-fluoro-
2-fluorobenzoylchloride
CCRIS 5914
HSDB 4261
EINECS 206-887-2
NSC 88304
UNII-Z4H017N76S
BRN 0636864
DTXSID3025330
Z4H017N76S
MFCD00000656
NSC-88304
2-Fluoro-benzoyl chloride
ortho-Fluorobenzoyl chloride
DTXCID005330
RAAGZOYMEQDCTD-UHFFFAOYSA-
EC 206-887-2
4-09-00-00951 (Beilstein Handbook Reference)
2-FLUOROBENZENECARBONYL CHLORIDE
2-FLUOROBENZOYL CHLORIDE [HSDB]
Benzoyl chloride, fluoro-
fluorobenzoyl chloride
2-fluorobenzoic acid chloride
oFluorobenzoyl chloride
2-fluorbenzoyl chloride
2-flurobenzoyl chloride
2-fluoro-benzoylchloride
o-fluoro-benzoyl chloride
Benzoyl chloride, ofluoro
2-fluoro benzoyl chloride
WLN: GVR BF
Benzoyl chloride, 2fluoro
SCHEMBL60101
2-fluoro benzoic acid chloride
2-Fluorobenzoyl chloride, 99%
CHEMBL1606202
alpha-chloro-2-fluorobenzaldehyde
2-fluoro-1-benzenecarbonyl chloride
NSC88304
Tox21_200637
STL183341
AKOS000121330
PB42721
O-FLUOROBENZENE CARBONYL CHLORIDE
NCGC00091418-01
NCGC00091418-02
NCGC00258191-01
CAS-393-52-2
PS-10795
F0195
NS00005399
EN300-19512
D70825
Q27294989
F2190-0058
o-Fluorobenzenecarbonyl chloride; o-Fluorobenzoyl chloride; 2-Fluoro-benzoic acid chloride
2-Fluoro-benzoyl Chloride; 2-Fluorobenzenecarbonyl Chloride; o-Fluorobenzoyl Chloride; NSC 88304;
206-887-2