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2-Fluorophenol

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Identification
Molecular formula
C6H5FO
CAS number
367-12-4
IUPAC name
2-fluorophenol
State
State

At room temperature, 2-fluorophenol is typically a liquid. It can solidify just below room temperature, reflecting its relatively low melting point. It is volatile and can evaporate if left in an open container.

Melting point (Celsius)
6.70
Melting point (Kelvin)
279.85
Boiling point (Celsius)
173.40
Boiling point (Kelvin)
446.55
General information
Molecular weight
112.11g/mol
Molar mass
112.1120g/mol
Density
1.2210g/cm3
Appearence

2-Fluorophenol is a colorless liquid compound. It has a distinct phenolic smell and is prone to browning when exposed to air and light over prolonged periods. The liquid may appear slightly yellow if impurities are present or due to degradation.

Comment on solubility

Solubility of 2-fluorophenol

2-fluorophenol, with the chemical formula C6H5F(OH), exhibits interesting solubility characteristics that can be summarized as follows:

  • Polar Nature: The presence of the hydroxyl group (-OH) makes 2-fluorophenol polar, which plays a significant role in its solubility in water.
  • Solubility in Water: 2-fluorophenol is moderately soluble in water due to hydrogen bonding between the hydroxyl group and water molecules.
  • Solubility in Organic Solvents: It also dissolves well in organic solvents such as ethanol and ether, highlighting its amphipathic nature.
  • pH Influence: The solubility can vary with pH changes, where more acidic conditions can increase solubility due to deprotonation of the hydroxyl group.

In summary, the solubility behavior of 2-fluorophenol is influenced by its **polar** structure and the *intermolecular interactions* it forms, allowing it to dissolve in both polar and non-polar solvents to a certain extent. As stated, "Solubility is the key to understanding interactions in a chemical environment," and 2-fluorophenol exemplifies this principle effectively.

Interesting facts

Interesting Facts about 2-Fluorophenol

2-Fluorophenol is a fascinating compound that features a fluorine atom substituted at the ortho position of the phenolic ring. As a derivative of phenol, this compound boasts a variety of intriguing properties and applications:

  • Versatile Intermediate: 2-Fluorophenol serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and various organic compounds. Its unique properties allow for the incorporation of additional functional groups, facilitating complex chemical reactions.
  • Influence of Fluorine: The presence of the fluorine atom significantly alters the electronic properties of the compound, enhancing its reactivity and solubility in many organic solvents. This influence plays a critical role in its utility in reaction pathways.
  • Applications in Research: In medicinal chemistry, 2-fluorophenol is often used in developing new drugs due to its ability to modulate biological activity. Studies have shown that fluorinated compounds can exhibit different binding affinities and bioactivities compared to their non-fluorinated counterparts.
  • Health and Safety Considerations: While 2-fluorophenol is valuable in the lab, it also requires careful handling. Its moderate toxicity necessitates the use of proper personal protective equipment and adherence to safety protocols during experimentation.

In summary, 2-fluorophenol is not just an ordinary compound; it is a remarkable piece of the chemical puzzle with substantial impact in various fields, particularly in drug design and synthesis. The world of fluorinated compounds offers endless possibilities for innovation and discovery, making this compound an exhilarating subject for both scientists and students alike.

Synonyms
2-FLUOROPHENOL
367-12-4
o-Fluorophenol
Phenol, 2-fluoro-
Phenol, o-fluoro-
1-Fluoro-2-hydroxybenzene
Fluorophenol
CCRIS 1226
2-fluoro-phenol
I9OW1NLY9R
EINECS 206-681-2
NSC 10294
BRN 1905112
DTXSID0047745
MFCD00002155
NSC-10294
DTXCID0027729
2-fluorohydroxybenzene
4-06-00-00770 (Beilstein Handbook Reference)
4-(2-FLUOROPHENOXY)-1-BUTANOL
Phenol, fluoro-
UNII-I9OW1NLY9R
oFluorophenol
2-fluorophenoxy
Phenol, ofluoro
2-fluoro phenol
ortho-fluorophenol
Phenol, 2fluoro
Phenol, 2-fluoro-; Phenol, o-fluoro- (6CI,7CI,8CI); 2-Fluorophenol; 1-Fluoro-2-hydroxybenzene; NSC 10294; o-Fluorophenol
1Fluoro2hydroxybenzene
2-Fluorophenol, 98%
SCHEMBL78212
CHEMBL224144
DTXSID001316872
NSC10294
Tox21_202915
STL264214
AKOS000118964
PS-9254
NCGC00260461-01
CAS-367-12-4
HY-41755
DB-028087
2-Fluorophenol 1000 microg/mL in Methanol
CS-0018719
F0150
NS00041725
EN300-19239
Q27280615
F0001-1049
1996-43-6
206-681-2
FP2