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2-Fluoropyridine

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Identification
Molecular formula
C5H4FN
CAS number
372-48-5
IUPAC name
2-fluoropyridine
State
State

At room temperature, 2-fluoropyridine exists as a liquid. Due to its low melting point, it remains in the liquid state under standard laboratory conditions.

Melting point (Celsius)
-47.00
Melting point (Kelvin)
226.15
Boiling point (Celsius)
131.30
Boiling point (Kelvin)
404.45
General information
Molecular weight
111.11g/mol
Molar mass
111.1070g/mol
Density
1.1390g/cm3
Appearence

2-Fluoropyridine is a colorless liquid with a distinctive aromatic odor. It is typically transparent in appearance and its liquid state allows it to be easily handled and measured in laboratory environments.

Comment on solubility

Solubility of 2-fluoropyridine

2-fluoropyridine, with the chemical formula C5H4FN, exhibits interesting solubility characteristics in various solvents. Its solubility can be examined through the following aspects:

  • Polarity: The presence of the fluorine atom introduces polarity to the molecule, enhancing its interactions with polar solvents.
  • Common Solvents: 2-fluoropyridine is generally soluble in:
    • Water - due to hydrogen bonding capabilities and its polar nature.
    • Alcohols - such as ethanol and methanol, which can effectively solvate the compound.
    • Organic Solvents - including dichloromethane and acetone, where it remains soluble due to its overall structure.
  • Temperature Effects: Like many compounds, its solubility can increase with temperature, allowing for greater dissolution in solvents at elevated temperatures.
  • Crystallization: 2-fluoropyridine can crystallize from concentrated solutions, particularly when cooled carefully.

In summary, the solubility of 2-fluoropyridine is strongly influenced by its molecular structure and the nature of the solvent used. Understanding these solubility properties is crucial for applications in organic synthesis and pharmaceutical research.

Interesting facts

Interesting Facts about 2-Fluoropyridine

2-Fluoropyridine is a fascinating compound that merges the properties of fluorine with the aromatic nature of pyridine. Here are some engaging insights into this intriguing substance:

  • Structure and Bonding: The presence of a fluorine atom at the 2-position of the pyridine ring influences the electronic properties of the molecule, enhancing its reactivity and making it an interesting subject of study in organic chemistry.
  • Applications in Synthesis: 2-Fluoropyridine is prominently used as a building block in pharmaceuticals and agrochemicals. Its unique properties enable the design of more effective and targeted compounds.
  • Role as a Solvent: This compound often serves as an effective solvent or reagent in various organic reactions, showcasing its versatility in laboratory settings.
  • Biological Activity: Research has indicated that compounds containing the fluoropyridine moiety may exhibit biological activity, making them candidates for drug discovery and development.
  • Fluorine's Impact: The incorporation of fluorine into organic compounds frequently alters their biological behavior and stability, which is why studying compounds like 2-fluoropyridine is crucial for chemists aiming to innovate in drug design.

As one of the halogenated heterocycles, 2-fluoropyridine exemplifies how simple modifications can lead to significant changes in a compound’s physicochemical properties and its applications in modern organic chemistry. This compound not only serves as a useful tool in synthetic methodologies but also stands out as a prime example of the fusion of elegance and functionality in chemical design.

Synonyms
2-Fluoropyridine
372-48-5
PYRIDINE, 2-FLUORO-
Pyridine, fluoro-
CCRIS 1725
AI3-28562
NSC 5077
EINECS 206-757-5
MFCD00006224
BRN 0001515
WKQ4JPY48S
DTXSID70190689
5-20-05-00397 (Beilstein Handbook Reference)
NSC-5077
o-fluoropyridine
2-Fluoropyridine; 2-Pyridyl Fluoride; NSC 5077;
fluoropyridine
2Fluoropyridine
2-fluoro-pyridine
Pyridine, 2fluoro
2-fluoranylpyridine
2-Pyridyl fluoride
2-Fluoro-pyridinium
2-Fluoropyridine #
UNII-WKQ4JPY48S
2-Fluoropyridine, 98%
CHEMBL1162360
DTXCID60113180
NSC5077
BCP23233
BBL010032
STK801408
AKOS000119365
AC-7018
CS-W011339
GS-6805
SB52269
BP-13083
DB-023956
DB-025029
F0217
NS00042189
EN300-20457
P16538
A823583
F0001-1073
206-757-5