Skip to main content

Hexadecylphosphorylcholine

ADVERTISEMENT
Identification
Molecular formula
C21H46NO4P
CAS number
77061-18-8
IUPAC name
2-[hexadecoxy(hydroxy)phosphoryl]oxyethyl-trimethyl-ammonium
State
State

At room temperature, Hexadecylphosphorylcholine is in a solid state. It remains stable under standard conditions and requires higher temperatures to transition into different states.

Melting point (Celsius)
119.00
Melting point (Kelvin)
392.15
Boiling point (Celsius)
446.00
Boiling point (Kelvin)
719.15
General information
Molecular weight
407.58g/mol
Molar mass
407.0680g/mol
Density
1.0520g/cm3
Appearence

Hexadecylphosphorylcholine is typically a solid substance that can appear colorless or exhibit a white, crystalline form. Its texture and form may vary slightly depending on purity and specific formulation.

Comment on solubility

Solubility of 2-[hexadecoxy(hydroxy)phosphoryl]oxyethyl-trimethyl-ammonium

The compound 2-[hexadecoxy(hydroxy)phosphoryl]oxyethyl-trimethyl-ammonium (C21H46NO4P) presents a unique profile in terms of solubility. This is often influenced by its structural characteristics, mainly its long hydrophobic hexadecyl chain combined with a hydrophilic ammonium group. Here are several key points regarding its solubility:

  • Solvent Behavior: The compound is likely to exhibit limited solubility in nonpolar solvents due to the long hydrophobic tail. However, it may show moderate solubility in polar solvents, which can interact favorably with the ionic ammonium group.
  • Aqueous Solutions: In water, this compound's solubility can be significantly enhanced by the presence of ionic interactions, allowing the ammonium group to interact with water molecules.
  • Temperature Dependence: As is common with many phosphorous-containing compounds, solubility may increase with temperature, promoting better interaction between solute and solvent molecules.
  • Concentration Factors: Depending on concentration, the compound may form micelles, further affecting its effective solubility in aqueous environments.

In conclusion, the solubility of 2-[hexadecoxy(hydroxy)phosphoryl]oxyethyl-trimethyl-ammonium can be broadly characterized as variable, dependent on solvent choice and environmental conditions. Researchers should carefully consider these factors during experimental applications.

Interesting facts

Interesting Facts about 2-[hexadecoxy(hydroxy)phosphoryl]oxyethyl-trimethyl-ammonium

This fascinating compound belongs to the class of phospholipids, which are crucial components of cell membranes. With a unique combination of organic and inorganic elements, it exhibits some remarkable properties:

  • Biological Significance: The presence of a phosphorous atom in this compound indicates that it may play a role in biological processes, particularly in cellular signaling and membrane structure.
  • Amphiphilic Nature: Due to its hydrophobic hexadecyl tail and hydrophilic head group, this molecule can interact with both water and lipid environments, making it a key player in drug formulation and delivery systems.
  • Potential Applications: Researchers are exploring the use of compounds like this in the development of liposomes, which are promising for targeted drug delivery, gene therapy, and as vaccine carriers.
  • Surface Activity: The trimethylammonium group imparts surfactant properties, which can aid in stabilizing emulsions and foams, making it valuable in cosmetic formulations and food technology.
  • Research Frontiers: Ongoing studies are focused on how modifications in such phospholipids can enhance their biocompatibility and functionality in nanocarrier systems.

In summary, 2-[hexadecoxy(hydroxy)phosphoryl]oxyethyl-trimethyl-ammonium is not just a compound but a potential cornerstone in understanding and developing new biomaterials that reflect the intricate interplay between chemistry and biology. As we delve into the world of phospholipids, it emphasizes the importance of interdisciplinary approaches in modern chemical research.

Synonyms
SR-05000001456
NCI60_004639
Spectrum2_000679
Spectrum3_001988
n-hexadecylphosphonocholine
NCIMech_000602
SCHEMBL52690
BSPBio_003588
SPBio_000777
CHEMBL513021
KBio3_003000
PQLXHQMOHUQAKB-UHFFFAOYSA-O
SR-01000946573
SR-01000946573-1
SR-05000001456-1
SR-05000001456-2
SR-05000001456-6
BRD-A31811760-001-06-7
BRD-A31811760-002-01-6