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Isatin

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Identification
Molecular formula
C8H5NO2
CAS number
91-56-5
IUPAC name
2-hydroxy-1-(1-methylindol-3-yl)ethanone
State
State

Isatin is a solid at room temperature. It is stable under normal conditions.

Melting point (Celsius)
200.00
Melting point (Kelvin)
473.15
Boiling point (Celsius)
450.00
Boiling point (Kelvin)
723.15
General information
Molecular weight
147.14g/mol
Molar mass
147.1440g/mol
Density
1.5400g/cm3
Appearence

Isatin typically appears as a red-orange to dark brown solid when pure. It is crystalline in nature and may form a powder depending on its preparation.

Comment on solubility

Solubility of 2-hydroxy-1-(1-methylindol-3-yl)ethanone

The solubility of 2-hydroxy-1-(1-methylindol-3-yl)ethanone can be influenced by several factors, making it a topic of interest in the field of chemistry.

  • Polarity: This compound contains both hydrophilic (the -OH group) and hydrophobic (the indole ring) regions. As a result, its solubility in water can be moderate, as polar solvents may interact with the -OH group.
  • Solvent Choice: It is likely to exhibit higher solubility in organic solvents such as ethanol or dimethyl sulfoxide due to its non-polar character from the indole moiety. This aspect emphasizes the importance of selecting the appropriate solvent for dissolution.
  • Temperature: As with many organic compounds, an increase in temperature generally enhances solubility. Therefore, measurements should be taken into account at different temperatures to gauge maximum solubility.

In summary, the solubility of 2-hydroxy-1-(1-methylindol-3-yl)ethanone is a complex interplay between its molecular structure and the solvent environment. This compound may dissolve adequately in polar conditions but exhibits greater affinity in non-polar organic solvents. Understanding its solubility profile is essential for applications in pharmaceuticals and chemical synthesis.

Interesting facts

Interesting Facts about 2-Hydroxy-1-(1-methylindol-3-yl)ethanone

2-Hydroxy-1-(1-methylindol-3-yl)ethanone, often referred to in the scientific community as a unique derivative of indole, exhibits fascinating properties that pique the interest of chemists and biologists alike. This compound is particularly notable for its:

  • Biological Significance: 2-Hydroxy-1-(1-methylindol-3-yl)ethanone has been studied for its potential roles in various biological systems. Derivatives of indole are known to exhibit a range of biological activities, suggesting that this compound might have applications in pharmacology.
  • Functional Groups: Featuring both a hydroxyl (–OH) and a carbonyl (C=O) group, the compound's structure allows it to engage in varied chemical reactions, making it a valuable candidate for synthetic organic chemistry research.
  • Indole Ring System: The indole structure embedded in the compound is noteworthy for its prevalence in nature, particularly in tryptophan and various alkaloids. This connection positions 2-hydroxy-1-(1-methylindol-3-yl)ethanone within a broader chemical context that is rich with biological relevance.

Furthermore, research into the applications of this compound extends into fields such as:

  1. Drug Discovery: The indole framework is a longstanding scaffold in medicinal chemistry, paving the way for this compound to be explored as a lead structure for new drugs.
  2. Materials Science: Variants of indole derivatives are being examined for their utility in creating advanced materials due to their interesting electronic properties.

As a scientist studying compounds such as 2-hydroxy-1-(1-methylindol-3-yl)ethanone, it's exciting to consider the intersection of synthetic chemistry and biological utility. The potential for discovering new applications and mechanisms of action remains high, particularly in an era where interdisciplinary approaches often yield groundbreaking advances.

Synonyms
KETONE, HYDROXYMETHYL 1-METHYL-3-INDOLYL
23518-13-0
BRN 1530449
3-(Hydroxyacetyl)-1-methylindole
Indole, 3-(hydroxyacetyl)-1-methyl
2-hydroxy-1-(1-methylindol-3-yl)ethanone
1-methyl-3-hydroxyacetylindole
DTXSID70178109