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2-hydroxy-1-(2-methyl-1H-indol-3-yl)ethanone

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Identification
Molecular formula
C11H11NO2
CAS number
340-58-9
IUPAC name
2-hydroxy-1-(2-methyl-1H-indol-3-yl)ethanone
State
State

This compound typically exists as a solid at room temperature.

Melting point (Celsius)
100.00
Melting point (Kelvin)
373.20
Boiling point (Celsius)
404.60
Boiling point (Kelvin)
677.80
General information
Molecular weight
189.23g/mol
Molar mass
189.2290g/mol
Density
1.1960g/cm3
Appearence

This compound is typically a yellow to light brown crystalline solid. It has a characteristic odor and exists in powder form at room temperature. The appearance might slightly vary depending on the degree of purity and the presence of impurities.

Comment on solubility

Solubility of 2-hydroxy-1-(2-methyl-1H-indol-3-yl)ethanone

The solubility of 2-hydroxy-1-(2-methyl-1H-indol-3-yl)ethanone can be characterized by various factors such as polarity, molecular structure, and interactions with solvents. Here are some noteworthy points regarding its solubility:

  • Polarity: The presence of the hydroxyl group (-OH) suggests that this compound possesses polar characteristics, which typically enhances its solubility in polar solvents like water.
  • Hydrogen Bonding: The hydroxyl group's ability to form hydrogen bonds increases the likelihood of solubility in polar environments. This allows 2-hydroxy-1-(2-methyl-1H-indol-3-yl)ethanone to interact favorably with other polar molecules.
  • Solvent Compatibility: It is expected to be more soluble in organic solvents such as ethanol or methanol, where intermolecular factors promote solvation.
  • Crystal Structure: The solid-state properties and crystal lattice energy may also play a crucial role in determining how easily this compound dissolves in various solvents.

In conclusion, while the solubility profile of 2-hydroxy-1-(2-methyl-1H-indol-3-yl)ethanone suggests a favorable interaction with polar solvents, empirical testing is often necessary to determine precise solubility limits. Understanding these factors can significantly aid in both practical applications and further research endeavors.

Interesting facts

Interesting Facts About 2-hydroxy-1-(2-methyl-1H-indol-3-yl)ethanone

2-hydroxy-1-(2-methyl-1H-indol-3-yl)ethanone, often referred to as a derivative of indole, presents a fascinating area of study in organic chemistry due to its unique structure and potential applications.

Key Features of the Compound:

  • Indole Derivative: This compound is closely related to indole, a crucial structure found in many natural products and pharmaceuticals. The indole structure is known for its aromatic properties and is a significant motif in many biologically active compounds.
  • Functional Groups: The presence of a hydroxy (-OH) group and a ketone (>C=O) within the compound enhances its reactivity and the potential for forming hydrogen bonds, which can influence its solubility and interactions with biological molecules.
  • Chemical Reactivity: The 2-hydroxy group suggests that the compound can participate in various chemical reactions such as esterification and acylation, making it valuable for synthetic organic chemistry.

This compound has attracted attention for its potential roles in several important fields:

Applications and Research:

  • Pharmaceuticals: The indole structure is a core scaffold in many drugs, and derivatives like this may exhibit biological activity that warrants exploration in medicinal chemistry.
  • Natural Product Synthesis: Due to its structure, it is a compound of interest for the synthesis of natural products that can have useful medicinal properties.
  • Material Science: The chemical properties of this compound may also find applications in advanced materials like sensors and organic electronics.

As noted by researchers, "The exploration of indole derivatives is essential for the discovery of new therapeutic agents." This underscores the significance of compounds like 2-hydroxy-1-(2-methyl-1H-indol-3-yl)ethanone in advancing our understanding of chemistry and potential innovations in health and technology.

In summary, the study of 2-hydroxy-1-(2-methyl-1H-indol-3-yl)ethanone not only enhances our understanding of indole chemistry but also opens doors to numerous practical applications in various scientific fields.

Synonyms
BRN 0142720
KETONE, HYDROXYMETHYL 2-METHYL-3-INDOLYL
27463-04-3
3-(2-Hydroxyacetyl)-2-methylindole
Indole, 3-(hydroxyacetyl)-2-methyl
DTXSID00181883
5-21-12-00374 (Beilstein Handbook Reference)
RefChem:350463
DTXCID40104374
2-methyl-3-hydroxyacetylindole
AKOS006242281