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Methadone hydrochloride

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Identification
Molecular formula
C21H28ClNO2
CAS number
1095-90-5
IUPAC name
(2-hydroxy-1-methyl-2-phenyl-butyl)-methyl-ammonium;chloride
State
State

At room temperature, methadone hydrochloride is in a solid state, particularly as a white crystalline powder. Its solid form is amenable to pharmaceutical formulation, such as tablets or solutions, after appropriate processing.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.15
Boiling point (Celsius)
333.00
Boiling point (Kelvin)
606.15
General information
Molecular weight
345.21g/mol
Molar mass
345.2110g/mol
Density
1.0043g/cm3
Appearence

Methadone hydrochloride appears as a crystalline white powder. It is generally odorless and has a bitter taste. The compound is soluble in water, giving it practicality for various pharmaceutical applications.

Comment on solubility

Solubility of (2-hydroxy-1-methyl-2-phenyl-butyl)-methyl-ammonium;chloride

The solubility of (2-hydroxy-1-methyl-2-phenyl-butyl)-methyl-ammonium chloride can present intriguing characteristics that warrant discussion. This compound, with its quaternary ammonium structure, demonstrates polar characteristics due to the presence of hydroxyl and ammonium functional groups.

In general, the solubility in water can be influenced by several factors:

  • Hydrogen Bonding: The hydroxyl group allows for the formation of hydrogen bonds with water molecules, enhancing its solubility.
  • Ionic Interactions: As a quaternary ammonium salt, the ionic nature of the chloride counterion contributes to its solubility in polar solvents like water.
  • Hydrophobic Interactions: The aromatic phenyl group, while being lipophilic, may reduce the overall solubility in purely aqueous solutions, indicating a potential *compromise* between solubility and affinity for organic solvents.

Thus, we can summarize the solubility conditions as follows:

  1. Likely **soluble** in water due to polar functional groups.
  2. May exhibit **limited solubility** in non-polar organic solvents.
  3. The **overall solubility** profile may change depending on environmental factors such as temperature and pH.

To encapsulate, while (2-hydroxy-1-methyl-2-phenyl-butyl)-methyl-ammonium chloride shows promise for solubility in polar media, the precise solubility behavior can be complex, driven by its molecular architecture and interactions in various solvents.

Interesting facts

Interesting Facts about (2-hydroxy-1-methyl-2-phenyl-butyl)-methyl-ammonium;chloride

This compound, also known as a quaternary ammonium salt, is fascinating not only for its structure but also for its applications. Quaternary ammonium compounds generally possess unique properties that can be harnessed in various fields.

Applications and Uses

  • Surfactants: Many quaternary ammonium compounds serve as surfactants, lowering the surface tension between liquids, which is beneficial in detergents and cleaning products.
  • Antimicrobial Properties: This specific compound exhibits notable antimicrobial effectiveness, making it useful in disinfectants and antiseptics.
  • Pharmaceuticals: Its structure allows for potential applications in drug delivery systems, enhancing the solubility and stability of various therapeutic agents.

Structural Features

The intriguing structure of this compound includes:

  • Hydroxyl Group: The presence of the hydroxyl group contributes to hydrogen bonding, enhancing its solubility in polar solvents.
  • Phenyl Group: The phenyl moiety can influence the lipophilicity of the compound, which is critical in drug formulation processes.
  • Methyl Ammonium Cation: This part of the molecule provides a positive charge that is essential for its role as a quaternary ammonium compound.

Research Insights

Researchers are continuously exploring the properties of compounds like this one. Some noted areas of study include:

  • Environmental Impact: Studies are underway to evaluate the biodegradability and environmental fate of quaternary ammonium compounds.
  • Synergistic Effects: When combined with other agents, this compound may exhibit enhanced efficacy, leading to more effective formulations.
  • Resistance Development: Understanding the mechanisms of resistance against microbial organisms is critical for developing better disinfectants.

In summary, (2-hydroxy-1-methyl-2-phenyl-butyl)-methyl-ammonium;chloride is a dynamic compound with diverse applications and structural characteristics that make it a subject of ongoing scientific interest and study. Its role in both industrial applications and research highlights the significance of quaternary ammonium compounds in chemistry.

Synonyms
25442-13-1
DTXSID60948318
2-(Methylamino)-3-phenylpentan-3-ol--hydrogen chloride (1/1)
RefChem:1061893
DTXCID401376551
BENZYL ALCOHOL, alpha-ETHYL-alpha-(1-(METHYLAMINO)ETHYL)-, HYDROCHLORIDE
alpha-Ethyl-alpha-(1-(methylamino)ethyl)benzyl alcohol hydrochloride
Benzenemethanol, alpha-ethyl-alpha-(1-(methylamino)ethyl)-, hydrochloride