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Diphenhydramine hydrochloride

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Identification
Molecular formula
C17H22ClNO
CAS number
147-24-0
IUPAC name
(2-hydroxy-1,2-diphenyl-ethyl)ammonium;chloride
State
State

At room temperature, diphenhydramine hydrochloride is typically a solid. It is stable under normal conditions of use and storage.

Melting point (Celsius)
166.00
Melting point (Kelvin)
439.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
291.82g/mol
Molar mass
291.8190g/mol
Density
1.0830g/cm3
Appearence

Diphenhydramine hydrochloride typically appears as a white or off-white crystalline powder. It is odorless and has a bitter taste. The compound is often seen in the form of tablets or capsules when used as a medication.

Comment on solubility

Solubility of (2-hydroxy-1,2-diphenyl-ethyl)ammonium chloride

(2-hydroxy-1,2-diphenyl-ethyl)ammonium chloride, often referred to for its intriguing structure, displays specific solubility characteristics that are quite noteworthy. The solubility of this compound can be influenced by several factors:

  • Polarity: The presence of the ammonium group contributes to its polar nature, facilitating its solubility in polar solvents, such as water.
  • Temperature: Like many ionic compounds, its solubility typically increases with temperature. Higher temperatures can enhance the solvation process and help dissolve larger quantities.
  • pH Levels: The solubility can be affected by the pH of the solution; at higher pH levels, the hydroxyl group may participate in interactions that further affect solubility.
  • Concentration: At certain concentrations, a saturation point might be reached, leading to the formation of a precipitate if the solution cannot accommodate more of the compound.

In terms of practical application, it is often said that "solubility is key"—without proper solubility, compounds like (2-hydroxy-1,2-diphenyl-ethyl)ammonium chloride cannot be effectively utilized. Research and experimentation can illuminate the exact solubility limits, making it crucial for those working with this compound to ascertain its behavior in various environments. Overall, understanding the solubility is fundamental in its applications within chemical processes and formulations.

Interesting facts

Interesting Facts about (2-hydroxy-1,2-diphenyl-ethyl)ammonium chloride

(2-hydroxy-1,2-diphenyl-ethyl)ammonium chloride, commonly known as a quaternary ammonium compound, embodies a fascinating intersection of chemistry and biopharmaceutical applications. Here are some noteworthy aspects:

  • Biological Activity: This compound has been studied for its potential biological activity, including antimicrobial properties. Its unique structure makes it an intriguing candidate for drug development, especially in the realm of treating infections.
  • Quaternary Ammonium Significance: The quaternary nitrogen atom in its structure is positively charged, which increases its solubility in water compared to its tertiary counterparts, making it useful in a variety of formulations.
  • Structural Versatility: With two phenyl groups attached, (2-hydroxy-1,2-diphenyl-ethyl)ammonium chloride exhibits different conformations that can affect its reactivity and interactions with biological targets.
  • Utilization in Synthesis: This compound is often utilized in synthetic organic chemistry as an intermediate. Its hydroxyl group adds to its reactivity, allowing chemists to perform various transformations and syntheses.
  • Research Impacts: Scientists continue to explore the implications of this compound in drug delivery systems due to its ability to enhance permeation across cellular membranes.

As a chemistry student or scientist, diving deeper into (2-hydroxy-1,2-diphenyl-ethyl)ammonium chloride not only broadens your comprehension of quaternary ammonium compounds but also reveals their immense potential in the medical field. Exploring such compounds is essential for fostering innovation in pharmaceuticals.

Synonyms
Diphenylethanolamine hydrochloride
NSC 10001
Ethanol, 2-amino-1,2-diphenyl-, hydrochloride
beta-Amino-alpha-phenylbenzeneethanol hydrochloride
Benzeneethanol, beta-amino-alpha-phenyl-, hydrochloride
alpha,beta-Diphenyl-beta-oxyaethylaminhydrochlorid [German]
BENZYL ALCOHOL, alpha-(alpha-AMINOBENZYL)-, HYDROCHLORIDE
AKOS004903362
alpha,beta-Diphenyl-beta-oxyaethylaminhydrochlorid