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4-Hydroxyquinolin-2(1H)-one

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Identification
Molecular formula
C9H7NO2
CAS number
3302-31-0
IUPAC name
2-hydroxy-1H-quinolin-4-one
State
State

At room temperature, 4-Hydroxyquinolin-2(1H)-one is in a solid state.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.00
Boiling point (Celsius)
362.50
Boiling point (Kelvin)
635.60
General information
Molecular weight
161.16g/mol
Molar mass
161.1560g/mol
Density
1.3058g/cm3
Appearence

4-Hydroxyquinolin-2(1H)-one appears as a yellow crystalline solid. It is often seen in a powdered form.

Comment on solubility

Solubility of 2-hydroxy-1H-quinolin-4-one

2-hydroxy-1H-quinolin-4-one, a compound known for its intriguing chemical structure, exhibits varying solubility characteristics that are important for its applications. When exploring the solubility of this compound, consider the following points:

  • Solvent Dependence: 2-hydroxy-1H-quinolin-4-one is generally soluble in organic solvents, such as ethanol, methanol, and dichloromethane. However, it displays limited solubility in water, which may pose challenges in certain reactions or applications.
  • pH Sensitivity: The solubility can significantly change with pH levels. The compound, being a phenolic derivative, can undergo protonation or deprotonation, influencing its solubility. An increase in pH can enhance its solubility due to the formation of anions.
  • Temperature Variability: Higher temperatures generally promote solubility for many compounds, including 2-hydroxy-1H-quinolin-4-one. Thus, heating the solvent may improve the dissolution of this compound in organic solvents.

In conclusion, understanding the solubility behavior of 2-hydroxy-1H-quinolin-4-one can greatly enhance its utility in both research and industry. As emphasized, careful selection of solvents and consideration of environmental conditions are crucial for achieving optimal solubility for practical applications.

Interesting facts

Interesting Facts about 2-Hydroxy-1H-Quinolin-4-One

2-Hydroxy-1H-quinolin-4-one is a fascinating compound that has captured the attention of chemists and researchers due to its unique structure and potential applications. Here are some intriguing aspects of this compound:

  • Structural Significance: The compound features a quinoline backbone, which is a bicyclic structure known for its aromatic properties. The presence of the hydroxyl group (–OH) at the 2-position enhances its reactivity and chemical behavior, making it a valuable intermediate in organic synthesis.
  • Biological Activity: Research has shown that derivatives of this compound exhibit a range of biological activities. Some studies suggest its potential as an antimicrobial, antitumor, and anti-inflammatory agent, opening doors for possible therapeutic uses.
  • Fluorescent Properties: One of the remarkable features of 2-hydroxy-1H-quinolin-4-one is its fluorescence. This characteristic makes it useful in applications such as fluorescent probes and in the field of bioimaging.
  • Metal Complexation: This compound can form complexes with various metal ions, which leads to the investigation of its use in coordination chemistry. Such complexes may have applications in catalysis and material science.
  • Potential in Material Science: The unique properties of 2-hydroxy-1H-quinolin-4-one suggest its role in developing advanced materials, such as organic light-emitting diodes (OLEDs) and solar cells, which are essential for future energy solutions.

In summary, 2-hydroxy-1H-quinolin-4-one is much more than just a compound; it represents a bridge between chemistry and pharmaceutical sciences. As ongoing research continues to unravel its potential, we can anticipate exciting developments in various fields of study.