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Trimethoprim

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Identification
Molecular formula
C14H18ClNO3
CAS number
738-70-5
IUPAC name
[2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]ammonium;chloride
State
State

This compound is generally found in a solid state at room temperature.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
290.75g/mol
Molar mass
290.7530g/mol
Density
1.3000g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder, which is practically odorless.

Comment on solubility

Solubility of [2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]ammonium;chloride

The solubility of [2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]ammonium;chloride in various solvents is an intriguing aspect of its chemical behavior. This compound, due to the presence of both polar and nonpolar groups, exhibits unique solubility characteristics:

  • Water Solubility: Being a quaternary ammonium salt, it is generally expected to be soluble in water. This solubility arises from the ionic nature of the chloride ion interacting favorably with water molecules.
  • Organic Solvents: Its solubility can vary depending on the organic solvent used. For instance, polar solvents like methanol and ethanol may enhance solubility due to hydrogen bonding.
  • Effect of Temperature: As with many ionic compounds, solubility may increase with rising temperature, providing a greater degree of interaction with the solvent.

As a result, the solubility of [2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]ammonium;chloride may be best described as:

  • Generally soluble in water.
  • Variable in organic solvents, depending on their polarity.

Understanding these solubility dynamics is crucial for applications involving this compound, especially in fields such as pharmaceuticals and materials science.

Interesting facts

Interesting Facts about [2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]ammonium chloride

[2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]ammonium chloride, commonly referred to as a quaternary ammonium compound, plays a significant role in various fields of chemistry and biochemistry. Here are some fascinating insights about this compound:

  • Chemical Role: This compound acts primarily as a surfactant, which is vital in multiple applications, including cleansing and emulsifying agents.
  • Biological Importance: Compounds of similar structure are often studied for their potential biological activities, including antimicrobial and antifungal effects.
  • Synthetic Depth: The synthesis of this compound involves the reaction of a phenolic compound with an amine, making it a great case study in organic synthesis for students and researchers alike.
  • Functional Groups: The presence of hydroxyl and methoxy groups signifies that this compound may have interesting hydrogen-bonding capabilities and could influence its solubility and activity.
  • Research Applications: It's been shown in studies that compounds of this type can be utilized as drug delivery agents due to their ability to traverse biological membranes, making them of high interest in pharmacology.

As you delve deeper into the chemistry of quaternary ammonium compounds, you will appreciate the intricate balance between their chemical structure and biological function. These compounds are not just laboratory curiosities; they symbolize the intersection of chemical innovation and practical application. As one scientist aptly put it, "Understanding the nuances of such compounds can unearth pathways to new therapeutic solutions."


In summary, [2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]ammonium chloride offers a window into the world of organic chemistry, illustrating how careful manipulation of molecular structures can lead to compounds with varied and significant uses.

Synonyms
alpha-(Aminomethyl)-3,4,5-trimethoxy-benzyl alcohol hydrochloride
BENZYL ALCOHOL, alpha-(AMINOMETHYL)-3,4,5-TRIMETHOXY-, HYDROCHLORIDE
beta-Hydroxymescaline hydrochloride
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