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Vardenafil

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Identification
Molecular formula
C23H32N6O4
CAS number
224785-91-5
IUPAC name
(2-hydroxy-2-methyl-propyl) 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate
State
State
Solid form at room temperature, often in the form of tablets for pharmaceutical use.
Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
537.50
Boiling point (Kelvin)
810.65
General information
Molecular weight
488.54g/mol
Molar mass
488.6040g/mol
Density
1.3780g/cm3
Appearence

Vardenafil appears as a white to off-white crystalline solid. It is a chemically stable compound that is typically manufactured and used in a solid form.

Comment on solubility

Solubility of (2-hydroxy-2-methyl-propyl) 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate

The solubility of the compound (2-hydroxy-2-methyl-propyl) 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate is influenced by its complex structure and the presence of various functional groups. Here are some key points to consider:

  • Polarity: The compound contains polar functional groups, such as hydroxyl groups, which may enhance its solubility in polar solvents like water.
  • Hydrogen Bonding: The presence of hydroxyl (-OH) and carboxyl (-COOH) groups allows for potential hydrogen bonding interactions, which can significantly increase solubility in aqueous environments.
  • Log P Value: The octanol-water partition coefficient (log P) could provide insights into the hydrophilic or lipophilic character of the compound, aiding in predicting its solubility in various solvents.
  • Temperature Dependency: Solubility often increases with temperature, so assessing its solubility across a range of temperatures can yield important data.

In summary, the solubility of this compound may be favorable in polar solvents due to its functional groups and the potential for hydrogen bonding. However, detailed experimental data are needed to fully understand its solubility characteristics in different environments.

Interesting facts

Interesting Facts About (2-hydroxy-2-methyl-propyl) 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate

This intriguing compound, commonly referred to by its systematic name, showcases the fascinating intersection of organic chemistry and pharmacology. As a derivative of piperazine, it exemplifies how structural modifications can lead to diverse biological activity.

Chemical Features

  • Substituted piperazine: The piperazine ring in this compound is vital for enhancing activity since piperazine derivatives often exhibit significant therapeutic benefits.
  • Quinazoline moiety: The presence of a quinazoline group contributes to its potential as a pharmaceutical agent, especially in targeting certain biological pathways.
  • Hydroxy and methyl groups: These functional groups play crucial roles in ensuring solubility and reactivity, impacting the compound's overall pharmacokinetics.

Pharmacological Significance

This compound has garnered interest for its potential applications in treating various diseases. Research into similar compounds often emphasizes:

  • Antitumor properties: Quinazoline derivatives are frequently explored for their capability to inhibit tumor growth.
  • Neuroscientific applications: Piperazine components are known for their role in modulating neurotransmitter systems, which positions them favorably in studying neurological disorders.
  • Antimicrobial effects: The unique structure can also lead to novel antimicrobial agents, demonstrating versatility in medicinal chemistry.

Conclusion

The exploration of (2-hydroxy-2-methyl-propyl) 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate highlights the importance of structure-function relationships in drug design. As researchers continue to investigate its properties, this compound exemplifies the rich potential within the realm of synthetic organic chemistry.

Synonyms
HOQUIZIL
21560-59-8
Hoquizil [INN]
hoquizilo
2MP2H1GQ03
UNII-2MP2H1GQ03
DTXSID30175896
2-HYDROXY-2-METHYLPROPYL 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-1-PIPERAZINECARBOXYLATE
1-Piperazinecarboxylic acid, 4-(6,7-dimethoxy-4-quinazolinyl)-, 2-hydroxy-1-methylpropyl ester
1-PIPERAZINECARBOXYLIC ACID, 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-, 2-HYDROXY-2-METHYLPROPYL ESTER
hoquizilum
RefChem:146821
DTXCID1098387
(2-hydroxy-2-methylpropyl) 4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxylate
SCHEMBL1815190
CHEMBL2110858
WAA56059
NS00127026
560H598
Q27254983