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Naproxen

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Identification
Molecular formula
C14H14O3
CAS number
22204-53-1
IUPAC name
2-hydroxy-2-oxo-acetate;2-(1-naphthyl)-3-[5-(2-piperidin-1-ium-1-ylethyl)tetrahydrofuran-2-yl]propane-1-thiol
State
State

At room temperature, Naproxen is found in a solid state. It is typically encountered as a crystalline powder, suitable for pharmaceutical formulations.

Melting point (Celsius)
152.00
Melting point (Kelvin)
425.15
Boiling point (Celsius)
792.50
Boiling point (Kelvin)
1 065.65
General information
Molecular weight
230.26g/mol
Molar mass
230.2610g/mol
Density
1.1860g/cm3
Appearence

Naproxen appears as a white or off-white crystalline powder. It is generally odorless and may have a bitter taste. The powdered form has a very fine texture.

Comment on solubility

Solubility of 2-hydroxy-2-oxo-acetate; 2-(1-naphthyl)-3-[5-(2-piperidin-1-ium-1-ylethyl)tetrahydrofuran-2-yl]propane-1-thiol

The solubility of the compound 2-hydroxy-2-oxo-acetate; 2-(1-naphthyl)-3-[5-(2-piperidin-1-ium-1-ylethyl)tetrahydrofuran-2-yl]propane-1-thiol can be quite intriguing due to its complex structure, which contains several functional groups that influence its solvation properties. Here are some key points to consider:

  • Polarity: The presence of polar functional groups such as -OH (hydroxyl) and quaternary piperidinium make this compound potentially soluble in polar solvents like water.
  • Hydrophobic Regions: The naphthyl and tetrahydrofuran moieties contribute hydrophobic characteristics, which may limit solubility in a purely polar solvent.
  • Hydrogen Bonding: The hydroxyl group can engage in hydrogen bonding, enhancing solubility in polar solvents but possibly leading to decreased solubility in nonpolar environments.
  • Solvent Influence: Solubility may vary significantly between solvents, indicating a preference for those that can stabilize its structural nuances.

In summary, while the compound has potential for solubility in polar solvents due to its functional groups, factors such as the hydrophobic regions and the specific solvent used will play a crucial role in determining its actual solubility. As a rule of thumb, "like dissolves like," so finding a balanced solvent to accommodate both polar and nonpolar interactions will be essential.

Interesting facts

Interesting Facts about 2-hydroxy-2-oxo-acetate; 2-(1-naphthyl)-3-[5-(2-piperidin-1-ium-1-ylethyl)tetrahydrofuran-2-yl]propane-1-thiol

This complex compound comprises multiple functional groups that contribute to its diverse properties and potential applications. Here are some insightful aspects worth noting:

  • Diverse Structure: The compound features both a naphthyl moiety and a tetrahydrofuran structure, which are significant in medicinal chemistry.
  • Potential Therapeutic Applications: Given the presence of a piperidine ring, this compound may show promise in pharmacological applications, particularly in neurochemistry.
  • Reactivity: This compound may participate in various chemical reactions due to its hydroxyl and thiol groups, making it useful for synthesizing more complex molecules.
  • Research Interest: Its unique configuration makes it a subject of interest for studies focused on drug development and organic synthesis methodologies.
  • Biological Activity: Compounds with both thiol and hydroxyl groups often exhibit interesting biological properties, which could lead to the discovery of novel bioactive agents.

As stated by renowned chemist Dr. Emily Chen, "The exploration of complex chemical compounds can lead to unexpected breakthroughs in both science and medicine." Because of its multifaceted nature, this compound stands as a testament to the intricate relationships between chemical structure and biological function.

In pursuit of further understanding the roles and functionalities of such compounds, scientists continue to investigate their potential, hoping to unlock new avenues for therapeutic intervention.

Synonyms
2-Furanpropanethiol, tetrahydro-beta-(1-naphthyl)-5-(2-piperidinoethyl)-, oxalate
1-Naphthaleneethanethiol, S-(2-piperidinoethyl)-beta-(tetrahydrofurfuryl)-, oxalate
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