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Niflumic acid

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Identification
Molecular formula
C13H11NO2
CAS number
4394-00-7
IUPAC name
2-hydroxy-2-phenyl-N-(2-pyridyl)acetamide
State
State

At room temperature, niflumic acid is a solid. Being a crystalline compound, it maintains a rigid structure at ambient conditions.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.15
Boiling point (Celsius)
339.50
Boiling point (Kelvin)
612.65
General information
Molecular weight
282.30g/mol
Molar mass
282.2980g/mol
Density
1.2450g/cm3
Appearence

Niflumic acid appears as a pale yellow crystalline powder. Its crystals are moderately sized and can sometimes appear slightly beige.

Comment on solubility

Solubility of 2-hydroxy-2-phenyl-N-(2-pyridyl)acetamide

The solubility of 2-hydroxy-2-phenyl-N-(2-pyridyl)acetamide is influenced by its molecular structure and polarity. This compound contains both aromatic and polar functional groups, which affect its interactions with solvents.

Factors influencing solubility:

  • Polar groups: The presence of the hydroxyl (-OH) group enhances solubility in polar solvents such as water.
  • Aromatic rings: The phenyl and pyridyl groups contribute to hydrophobic characteristics, which can limit solubility in highly polar solvents.
  • Temperature: Solubility can increase with rising temperatures, allowing for greater dissolution of the compound.
  • pH levels: The solubility may vary with different pH levels, particularly due to the ionizable nature of the amide group.

In summary, the solubility of C13H12N2O in water is moderate, which suggests that while it can dissolve to some extent, it may exhibit varying dissolvability across different solvents based on the polar and non-polar interactions at play. For practical applications, it is advisable to conduct experiments to determine precise solubility values under specific conditions.

Interesting facts

Interesting Facts about 2-hydroxy-2-phenyl-N-(2-pyridyl)acetamide

2-hydroxy-2-phenyl-N-(2-pyridyl)acetamide, often referred to by its more common name, is a fascinating compound that has garnered attention in the fields of medicinal chemistry and pharmaceutical research. Here are some key points that highlight its importance:

  • Versatile Applications: This compound is recognized for its potential as a therapeutic agent. It has been studied for use in the treatment of various diseases, potentially due to its unique structural properties.
  • Biological Activity: The presence of the pyridyl group enhances its ability to interact with biological targets, making it a candidate for further investigation in drug development.
  • Hydroxyl Group Significance: The hydroxyl group (-OH) not only contributes to its solubility but also plays a crucial role in the formation of hydrogen bonds, which is essential for its reactivity and biological interactions.
  • Synthesis and Modification: Chemists continue to explore different synthetic pathways and modifications of this compound to improve its efficacy and reduce any potential side effects, showcasing the ongoing innovation within the realm of organic chemistry.
  • Research Potential: Its intriguing chemical properties make it an attractive subject for ongoing research, particularly in understanding how variations in its chemical structure can influence biological activity.

As chemists explore the intricate relationships between structure and function, compounds like 2-hydroxy-2-phenyl-N-(2-pyridyl)acetamide serve as vital links in the quest to develop more effective and targeted therapies. As one researcher aptly put it, "The beauty of chemistry lies in the endless possibilities of compound interactions and their potential to change lives."

In summary, 2-hydroxy-2-phenyl-N-(2-pyridyl)acetamide stands out as a compound of interest, integrating elements of organic chemistry, pharmacology, and therapeutic innovation.

Synonyms
2-hydroxy-2-phenyl-N-(pyridin-2-yl)acetamide
2-hydroxy-2-phenyl-N-pyridin-2-ylacetamide
CBMicro_000126
Oprea1_029784
SMSF0005459
STK321195
AKOS003377451
AKOS022076656
CB01299
BIM-0000084.P001
EU-0002822
2-hydroxy-2-phenyl-N-(2-pyridinyl)acetamide
AO-365/09869013
SR-01000411980
SR-01000411980-1