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Mandelic acid amide

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Identification
Molecular formula
C9H11NO2
CAS number
17199-29-0
IUPAC name
2-hydroxy-2-phenyl-propanamide
State
State

At room temperature, mandelic acid amide is a solid and is typically handled as a powder or crystalline substance.

Melting point (Celsius)
137.50
Melting point (Kelvin)
410.60
Boiling point (Celsius)
285.80
Boiling point (Kelvin)
559.00
General information
Molecular weight
165.19g/mol
Molar mass
165.1910g/mol
Density
1.2570g/cm3
Appearence

Mandelic acid amide appears as a white crystalline solid, which may present as fine, delicate crystals.

Comment on solubility

Solubility of 2-hydroxy-2-phenyl-propanamide

2-hydroxy-2-phenyl-propanamide, often known for its unique structure, exhibits interesting solubility properties in various solvents. The presence of both an amide and a hydroxyl functional group significantly influences its interactions with solvents.

Key Solubility Characteristics:

  • Polar Solvents: This compound is likely to be soluble in polar solvents such as water and ethanol due to hydrogen bonding capabilities.
  • Non-Polar Solvents: The presence of the phenyl group introduces some non-polar characteristics, meaning it may have limited solubility in non-polar solvents like hexane.
  • PH Dependence: The solubility can also vary with pH, particularly if protonation or deprotonation of the amide group occurs.

Many researchers have noted that "the interplay between hydrophobic and hydrophilic regions in the molecule plays a crucial role in determining solubility." Thus, while it is generally soluble in water and other polar media, careful consideration of solvent choice is necessary for effective application in various chemical processes.

In conclusion, understanding the solubility of 2-hydroxy-2-phenyl-propanamide is essential for its effective utilization in both lab and industrial settings. This compound exemplifies how molecular structure can dictate solubility behavior.

Interesting facts

Interesting Facts about 2-hydroxy-2-phenyl-propanamide

2-hydroxy-2-phenyl-propanamide, commonly known as an aromatic amide, is a fascinating compound that belongs to the family of amides, which play essential roles in both biological systems and industrial applications.

Key Characteristics

  • Biological Significance: Compounds like 2-hydroxy-2-phenyl-propanamide are often investigated for their potential therapeutic effects. They can be precursors to pharmaceuticals, thus drawing significant attention in medicinal chemistry.
  • Functional Versatility: The presence of both hydroxyl (–OH) and amide (–C(O)NH2) functional groups in this compound contributes to its reactivity and potential utility in various organic synthesis reactions.
  • Aromatic Properties: The phenyl group imparts significant stability to the compound, making it suitable for applications that require aromatic properties, contributing to the stability and reactivity of the molecule.

Applications

This compound has numerous applications in different fields:

  • Pharmaceuticals: Investigated for its role in drug formulation and development.
  • Materials Science: Can be employed in creating polymers with desirable characteristics.
  • Research: Useful for studying amide-related reactions and mechanisms in organic chemistry.

Did You Know?

Compounds such as 2-hydroxy-2-phenyl-propanamide emphasize the intricacies of organic chemistry. As one scientist aptly put it, “Every small change in molecular structure can lead to significant shifts in chemical behavior and properties.” This creates excitement, as the journey of exploring such compounds leads to new discoveries!

Overall, 2-hydroxy-2-phenyl-propanamide is a prime example of how simple molecular frameworks can hold profound implications in science and industry.

Synonyms
Atrolactamide
Themisone
2019-68-3
alpha-Phenyllactamid
alpha-Methylmendelamid
DL-Atrolactamide
2-Hydroxy-2-phenylpropionamid
M-144
2-Hydroxy-2-phenylpropionamide
2-Phenyl-2-hydroxypropionamide
UNII-SJ9132S4AW
2-Hydroxy-2-phenylpropylamide
SJ9132S4AW
alpha-Hydroxy-alpha-methylbenzeneacetamide
MANDELAMIDE, alpha-METHYL-
NSC 51066
NSC-51066
ATROLACTAMIDE [MI]
.alpha.-Hydroxy-.alpha.-phenylpropionamide
Benzeneacetamide, alpha-hydroxy-alpha-methyl-
ATROLACTAMIDE DL-FORM [MI]
ATROLACTAMIDE DL-FORM
ALPHA-HYDROXY-ALPHA-PHENYLPROPIONAMIDE
Benzeneacetamide, alpha-hydroxy-alpha-methyl-(9CI)
2-hydroxy-2-phenylpropanamide
Benzeneacetamide, alpha-hydroxy-alpha-methyl- (9CI)
Mandelamide, .alpha.-methyl-
NSC51066
SCHEMBL78236
Benzeneacetamide, .alpha.-hydroxy-.alpha.-methyl-
CHEMBL309487
2-Hydroxy-2-phenyl-propionamide
CHEBI:134797
DTXSID101043208
AKOS011494574
HY-119915
CS-0078359
NS00101077
Q27289242